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Management of Motor and Non-Motor Symptoms in Parkinson’s Disease
CNS Drugs, 2013Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects approximately 1 % of people over the age of 60 years. Accurate diagnosis and individualized assessment of the risks and benefits of available antiparkinsonian medications as well as specific clinical features and the phase of disease should guide treatment for ...
Fabienne, Sprenger, Werner, Poewe
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Fatigue in Parkinson's disease: Motor or non-motor symptom?
Parkinsonism & Related Disorders, 2013Fatigue is one of the most disabling symptoms in patients with Parkinson's disease (PD), with a significant impact on patients' quality of life. Clinical studies using ad hoc questionnaires showed that in PD fatigue is associated with non-motor as well motor symptoms.
FABBRINI, Giovanni +5 more
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Current Drug Targets, 2014
The term Parkinson’s disease has been changed in ‘Parkinson's diseases’ to describe different clinical entities observed in several studies investigating the existence of PD subtypes. PD patients could be grouped based on clinical features. By considering only motor symptoms, we can classically distinguish two groups: “ the tremorigen-form” and ...
LAURETANI, Fulvio +6 more
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The term Parkinson’s disease has been changed in ‘Parkinson's diseases’ to describe different clinical entities observed in several studies investigating the existence of PD subtypes. PD patients could be grouped based on clinical features. By considering only motor symptoms, we can classically distinguish two groups: “ the tremorigen-form” and ...
LAURETANI, Fulvio +6 more
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Quantification of the motor symptoms of Parkinson's disease
2017 8th International IEEE/EMBS Conference on Neural Engineering (NER), 2017Parkinson's disease (PD) is a neurodegenerative disorder and severely affects patients' daily lives. The diagnosis depends on the presence of one or more common motor symptoms of the disease. As PD is chronic and slowly progressive, the symptoms continue and worsen over a long period of time.
Qifan Bai +7 more
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Motor and non-motor symptoms in blepharospasm: clinical and pathophysiological implications
Journal of Neurology, 2019Patients with blepharospasm in addition to involuntary contraction of the orbicularis oculi muscle also have non-motor symptoms (psychiatric, sleep, cognitive, and ocular). In this paper, we investigated the relationship of non-motor with motor symptoms and the total burden of non-motor symptoms in patients with blepharospasm.
Gina Ferrazzano +2 more
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Non-motor symptoms: Identification and management
Parkinsonism & Related Disorders, 2007Non-motor symptoms are an important part of Parkinson's disease (PD) symptoms complex. They cause a significant burden on the quality of life of patients and their carers and remain a major cause of hospitalisation. Treatment of non-motor symptoms can be challenging as these symptoms are often unresponsive to conventional dopaminergic therapy. However,
Muzerengi, Sharon +2 more
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Initial Motor Symptoms of Parkinson Disease
The Neurologist, 2011Parkinson disease (PD) is characterized by a wide variety of motor and nonmotor symptoms. Although recently nonmotor symptoms have gained considerable relevance and interest, especially in advanced stages, motor symptoms define the main core of PD and are essential for clinical diagnosis.
Pedro J, Garcia Ruiz +2 more
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Treating the Motor Symptoms of Parkinson Disease
Continuum, 2016After a patient is diagnosed with Parkinson disease (PD), there are many therapeutic options available. This article provides examples of prototypical patients encountered in clinical practice and illustrates the various pharmacologic and nonpharmacologic treatment options for the motor symptoms of PD.Levodopa became available in the late 1960s and ...
John C, Morgan, Susan H, Fox
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Non‐motor symptoms in Parkinson’s disease
European Journal of Neurology, 2008Although still considered a paradigmatic movement disorder, Parkinson’s disease (PD) is associated with a broad spectrum of non‐motor symptoms. These include disorders of mood and affect with apathy, anhedonia and depression, cognitive dysfunction and hallucinosis, as well as complex behavioural disorders.
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Treatment of Motor Symptoms of Parkinson’s Disease
Neurologic ClinicsThe most effective pharmacologic intervention used to treat motor symptoms in Parkinson's disease is levodopa, which is available in various formulations, including newer continuous subcutaneous infusions. Dopamine agonists, monoamine oxidase-B enzyme inhibitors, catechol-O-methyltransferase enzyme inhibitors, amantadine, istradefylline, and ...
Luca, Marsili +3 more
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