Results 71 to 80 of about 17,995,485 (258)

Baricitinib ameliorates inflammatory and neuropathic pain in collagen antibody-induced arthritis mice by modulating the IL-6/JAK/STAT3 pathway and CSF-1 expression in dorsal root ganglion neurons

Arthritis Research & Therapy
Background Janus kinase (JAK) inhibitors, such as baricitinib, are widely used to treat rheumatoid arthritis (RA). Clinical studies show that baricitinib is more effective at reducing pain than other similar drugs.
Kenta Makabe, Hiroyuki Okada, Naohiro Tachibana, Hisatoshi Ishikura, Norihito Ito, Masaru Tanaka, Ryota Chijimatsu, Asuka Terashima, Fumiko Yano, Meiko Asaka, Dai Yanagihara, Shuji Taketomi, Takumi Matsumoto, Sakae Tanaka, Yasunori Omata, Taku Saito   +15 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Detailed statement of motor vehicle registrations (in dollars)

, 2002
Annual; Description based on: 2000; title from caption (viewed Aug.

core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Summary statement of motor vehicle registrations (in dollars)

, 2001
Annual; Description based on: 2000; title from caption (viewed Aug.

core  

Multiple influence of immune cells in the bone metastatic cancer microenvironment on tumors

Frontiers in Immunology
Bone is a common organ for solid tumor metastasis. Malignant bone tumor becomes insensitive to systemic therapy after colonization, followed by poor prognosis and high relapse rate.
Shixin Chen, Shixin Chen, Shixin Chen, Shixin Chen, Jiangchu Lei, Jiangchu Lei, Jiangchu Lei, Jiangchu Lei, Haochen Mou, Haochen Mou, Haochen Mou, Haochen Mou, Wenkan Zhang, Wenkan Zhang, Wenkan Zhang, Wenkan Zhang, Lingxiao Jin, Lingxiao Jin, Lingxiao Jin, Lingxiao Jin, Senxu Lu, Senxu Lu, Senxu Lu, Senxu Lu, Eloy Yinwang, Eloy Yinwang, Eloy Yinwang, Eloy Yinwang, Yucheng Xue, Yucheng Xue, Yucheng Xue, Yucheng Xue, Zhenxuan Shao, Zhenxuan Shao, Zhenxuan Shao, Zhenxuan Shao, Tao Chen, Tao Chen, Tao Chen, Tao Chen, Fangqian Wang, Fangqian Wang, Fangqian Wang, Fangqian Wang, Shenzhi Zhao, Shenzhi Zhao, Shenzhi Zhao, Shenzhi Zhao, Xupeng Chai, Xupeng Chai, Xupeng Chai, Xupeng Chai, Zenan Wang, Zenan Wang, Zenan Wang, Zenan Wang, Jiahao Zhang, Jiahao Zhang, Jiahao Zhang, Jiahao Zhang, Zengjie Zhang, Zengjie Zhang, Zengjie Zhang, Zengjie Zhang, Zhaoming Ye, Zhaoming Ye, Zhaoming Ye, Zhaoming Ye, Binghao Li, Binghao Li, Binghao Li, Binghao Li   +71 more
doaj   +1 more source

Nurse Educators' Knowledge and Perception of Clinical Reasoning at Nursing Technical Institutes [PDF]

Helwan International Journal for Nursing Research and Practice
Background: Clinical Reasoning is a complex process that involves a combination of knowledge, skills, and experience. It is important for nurses to work effectively as part of a healthcare team.
Hala Abd Elshafy
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Detailed statement of motor vehicle registrations (in units)

, 2007
Annual; Description based on: 2000; title from caption (viewed Aug.

core  

Interface-programmed regeneration of segmental bone defects with biomimetic mineral-coated β-TCP microparticles

Journal of Applied Biomaterials & Functional Materials
Large segmental bone defects remain difficult to treat: autografts are limited by supply and morbidity, while calcium-phosphate substitutes often deliver inconsistent outcomes.
Bingyao Chen, Lufeng Yao, Keye Chen, Yanguang Zhou, Chenxin Wang, Xiaodong Xu, Jinxia Ma, Jiayu Chen, Deting Xue, Zhaoming Ye, Xiaohua Yu   +10 more
doaj   +1 more source