Results 81 to 90 of about 17,995,485 (258)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Summary statement of motor vehicle registrations (in dollars)

, 2007
Annual; Description based on: 2000; title from caption (viewed Aug.

core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Summary statement of motor vehicle registrations (in dollars)

, 2005
Annual; Description based on: 2000; title from caption (viewed Aug.

core  

Synergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair

Bioactive Materials
In clinical practice, repairing osteochondral defects (OCDs) is challenging because of the complex cartilage/subchondral bone structure and intricate immunological microenvironment.
Changjian Lin, Chenting Ying, Yibo Xu, Yuxuan Zou, Ruihan Chen, Kaicheng Xu, Xiaoxiao Ji, Qihua Cao, Jiahui Weng, Lifeng Jiang, Chenyi Ye, Kai Xu, Yuzhe He, Weijun Li, Lidong Wu, Jisheng Ran, Yan Xiong, Xiaohua Yu, Jiapeng Bao   +18 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Detailed statement of motor vehicle registrations (in units)

, 2002
Annual; Description based on: 2000; title from caption (viewed Aug.

core  

Therapeutic potential of mesenchymal stem cell-derived exosomes in skeletal diseases

Frontiers in Molecular Biosciences
Skeletal diseases impose a considerable burden on society. The clinical and tissue-engineering therapies applied to alleviate such diseases frequently result in complications and are inadequately effective.
Xiaobo Yang, Xiaobo Yang, Xiaobo Yang, Xiaobo Yang, Shaodian Zhang, Shaodian Zhang, Shaodian Zhang, Shaodian Zhang, Jinwei Lu, Jinwei Lu, Jinwei Lu, Jinwei Lu, Xiaoling Chen, Tian Zheng, Tian Zheng, Tian Zheng, Tian Zheng, Rongxin He, Rongxin He, Rongxin He, Rongxin He, Chenyi Ye, Chenyi Ye, Chenyi Ye, Chenyi Ye, Jianbin Xu, Jianbin Xu, Jianbin Xu, Jianbin Xu   +28 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Detailed statement of motor vehicle registrations (in dollars)

, 2006
Annual; Description based on: 2000; title from caption (viewed Aug.

core