Results 81 to 90 of about 4,518,026 (355)

GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]

, 2013
Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes, Csilla Nemes, Eszter Varga, Jalving M., Melinda K. Pirity, Nuttha Klincumhom, Zsuzsanna Polgar   +6 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

X-linked deletion of Crossfirre, Firre, and Dxz4 in vivo uncovers diverse phenotypes and combinatorial effects on autosomes

Nature Communications
The lncRNA Crossfirre was identified as an imprinted X-linked gene, and is transcribed antisense to the trans-acting lncRNA Firre. The Firre locus forms an inactive-X-specific interaction with Dxz4, both loci providing the platform for the largest ...
Tim P. Hasenbein, Sarah Hoelzl, Zachary D. Smith, Chiara Gerhardinger, Marion O. C. Gonner, Antonio Aguilar-Pimentel, Oana V. Amarie, Lore Becker, Julia Calzada-Wack, Nathalia R. V. Dragano, Patricia da Silva-Buttkus, Lillian Garrett, Sabine M. Hölter, Markus Kraiger, Manuela A. Östereicher, Birgit Rathkolb, Adrián Sanz-Moreno, Nadine Spielmann, Wolfgang Wurst, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Alexander Meissner, Stefan Engelhardt, John L. Rinn, Daniel Andergassen   +25 more
doaj   +1 more source

LSH mediates gene repression through macroH2A deposition

Nature Communications, 2020
The human ICF 4 syndrome is caused by mutation of the chromatin remodeller LSH. Here, the authors show that LSH depletion disrupts the ability of histone variant macroH2A to insert into chromatin and silence transcription.
Kai Ni, Jianke Ren, Xiaoping Xu, Yafeng He, Richard Finney, Simon M. G. Braun, Nathaniel A. Hathaway, Gerald R. Crabtree, Kathrin Muegge   +8 more
doaj   +1 more source

A Comment on Budach's Mouse-in-an-Octant Problem [PDF]

, 2013
Budach's Mouse-in-an-Octant Problem (attributed to Lothar Budach in a 1980 article by van Emde Boas and Karpinski) concerns the behaviour of a very simple finite-state machine ("the mouse") moving on the integer two-dimensional grid.
Ben-Amram, Amir M.
core  

Olfactory variation in mouse husbandry and its implications for refinement and standardisation: UK survey of non-animal scents [PDF]

, 2016
With their highly sensitive olfactory system, the behaviour and physiology of mice are not only influenced by the scents of conspecifics and other species, but also by many other chemicals in the environment. The constraints of laboratory housing limit a
Burn, C C, Lopez-Salesansky, N, Mazlan, N H, Wells, D J, Whitfield, L E   +4 more
core   +3 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice

Scientific Reports, 2017
Group-housed male mice exhibit aggressive behaviour towards their cage mates and form a social hierarchy. Here, we describe how social hierarchy in standard group-housed conditions affects behaviour and gene expression in male mice.
Yasuyuki Horii, Tatsuhiro Nagasawa, Hiroyuki Sakakibara, Aki Takahashi, Akira Tanave, Yuki Matsumoto, Hiromichi Nagayama, Kazuto Yoshimi, Michiko T. Yasuda, Kayoko Shimoi, Tsuyoshi Koide   +10 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Claudin-12 is not required for blood–brain barrier tight junction function

Fluids and Barriers of the CNS, 2019
Background The blood–brain barrier (BBB) ensures central nervous system (CNS) homeostasis by strictly controlling the passage of molecules and solutes from the bloodstream into the CNS.
Mariana Castro Dias, Caroline Coisne, Pascale Baden, Gaby Enzmann, Lillian Garrett, Lore Becker, Sabine M. Hölter, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Urban Deutsch, Britta Engelhardt   +10 more
doaj   +1 more source