Results 101 to 110 of about 2,749,540 (299)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Resveratrol Ameliorates Imiquimod-Induced Psoriasis-Like Mouse Model via Reducing Macrophage Infiltration and Inhibiting Glycolysis

Journal of Inflammation Research, 2023
Yazhuo Wang,1,2 Cong Qi,1,2 Fang Feng,3 Xueqing Hu,3 Ning Zhao,1,2 Jingxia Zhao,1 Tingting Di,1 Yujiao Meng,1 Danyang Yang,1,2 Haoyue Zhu,1,2 Xiawei Zhang,1,2 Ping Li,1 Yan Wang1 1Beijing Hospital of Traditional Chinese Medicine, Capital Medical ...
Wang Y, Qi C, Feng F, Hu X, Zhao N, Zhao J, Di T, Meng Y, Yang D, Zhu H, Zhang X, Li P, Wang Y   +12 more
doaj  

Acute perioperative-stress-induced increase of atherosclerotic plaque volume and vulnerability to rupture in apolipoprotein-E-deficient mice is amenable to statin treatment and IL-6 inhibition

Disease Models & Mechanisms, 2015
Myocardial infarction and stroke are frequent after surgical procedures and consume a considerable amount of benefit of surgical therapy. Perioperative stress, induced by surgery, is composed of hemodynamic and inflammatory reactions.
Henrike Janssen, Christian S. Wagner, Philipp Demmer, Simone Callies, Gesine Sölter, Houra Loghmani-khouzani, Niandan Hu, Harald Schuett, Uwe J. F. Tietge, Gregor Warnecke, Jan Larmann, Gregor Theilmeier   +11 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A decade progress in the phenotyping of AppNL-G-F knock-in mouse model of Alzheimer’s disease

Neuroscience Research
Numerous mouse models of Alzheimer’s disease (AD) have developed since the discovery of mutations causing familial AD. These models successfully recapitulate the progressive amyloid pathology over time, thus serving as indispensable tools for improving ...
Tatsuya Manabe, Takashi Saito
doaj   +1 more source

A simple mouse model of pericardial adhesions

Journal of Cardiothoracic Surgery, 2019
Background Postoperative pericardial adhesions are considered a risk factor for redo cardiac surgery. Several large- and medium-size animal models of pericardial adhesions have been reported, but small animal models for investigating the development of ...
Ai Kojima, Tomohisa Sakaue, Mikio Okazaki, Fumiaki Shikata, Mie Kurata, Yuuki Imai, Hirotomo Nakaoka, Junya Masumoto, Shunji Uchita, Hironori Izutani   +9 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Geometry Processing of Conventionally Produced Mouse Brain Slice Images

, 2017
Brain mapping research in most neuroanatomical laboratories relies on conventional processing techniques, which often introduce histological artifacts such as tissue tears and tissue loss.
Agarwal, Nitin, Meenakshisundaram, Gopi, Xu, Xiangmin   +2 more
core   +1 more source