Results 221 to 230 of about 1,627,700 (267)
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Clinics in Dermatology, 2004
Insights into the etiology of human obesity have arisen from the study of animal models. Animal models of obesity are also important for the development of future treatments of obesity. An agouti mouse mutation resulting in obese, yellow mice was described over a century ago and in 1992 agouti was cloned, making it the first obesity gene characterized ...
Carroll, Levi +2 more
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Insights into the etiology of human obesity have arisen from the study of animal models. Animal models of obesity are also important for the development of future treatments of obesity. An agouti mouse mutation resulting in obese, yellow mice was described over a century ago and in 1992 agouti was cloned, making it the first obesity gene characterized ...
Carroll, Levi +2 more
openaire +3 more sources
Mouse Models of Phaeohyphomycosis
2023Infections by dematiaceous fungi especially phaeohyphomycosis are an emerging group of infectious diseases worldwide with a variety of clinical presentations. The mouse model is a useful tool for studying phaeohyphomycosis, which can mimic dematiaceous fungal infections in humans.
Yi, Zhang, Ruoyu, Li
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Mouse Model for Pyelonephritis
Current Protocols in Immunology, 2013AbstractThis unit describes a simple way to induce pyelonephritis in female mice using uropathogenic Escherichia coli (UPEC). Methods for culturing and preparing working stocks of UPEC are provided. Protocols to measure the bacterial load in the murine kidney following the establishment of pyelonephritis by determining the bacterial colony forming ...
André P, Tittel +2 more
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2014
Severe thermal injury induces immunosuppression, involving all parts of the immune system, especially when large fractions of the total body surface area are affected. An animal model was established to characterize the burn-induced immunosuppression. In our novel mouse model a 6 % third-degree burn injury was induced with a hot-air blower.
Henrik, Calum +2 more
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Severe thermal injury induces immunosuppression, involving all parts of the immune system, especially when large fractions of the total body surface area are affected. An animal model was established to characterize the burn-induced immunosuppression. In our novel mouse model a 6 % third-degree burn injury was induced with a hot-air blower.
Henrik, Calum +2 more
openaire +2 more sources
Annual Review of Pathology: Mechanisms of Disease, 2011
Genetically engineered mouse models have significantly contributed to our understanding of cancer biology. They have proven to be useful in validating gene functions, identifying novel cancer genes and tumor biomarkers, gaining insight into the molecular and cellular mechanisms underlying tumor initiation and multistage processes of tumorigenesis, and
Dong-Joo, Cheon, Sandra, Orsulic
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Genetically engineered mouse models have significantly contributed to our understanding of cancer biology. They have proven to be useful in validating gene functions, identifying novel cancer genes and tumor biomarkers, gaining insight into the molecular and cellular mechanisms underlying tumor initiation and multistage processes of tumorigenesis, and
Dong-Joo, Cheon, Sandra, Orsulic
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2023
Animal models have been crucial in understanding the pathogenesis and developing novel therapeutic approaches for fungal infections in general. This is especially true for mucormycosis, which has a low incidence but is often fatal or debilitating.
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Animal models have been crucial in understanding the pathogenesis and developing novel therapeutic approaches for fungal infections in general. This is especially true for mucormycosis, which has a low incidence but is often fatal or debilitating.
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2018
Mouse models are critical for delineating the mechanisms that underlie asthma pathogenesis and developing new treatments. In this chapter we describe four different asthma models that offer unique benefits and allow investigators to answer distinct research questions.
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Mouse models are critical for delineating the mechanisms that underlie asthma pathogenesis and developing new treatments. In this chapter we describe four different asthma models that offer unique benefits and allow investigators to answer distinct research questions.
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Physiology & Behavior, 1982
A model of alcoholism should demonstrate self-administration of alcohol by the animal and a withdrawal syndrome when the animal no longer has access to the drug. A mouse model is described that meets these criteria and enables the induction of "alcoholism" in a large number of animals within a short period of time.
H, Rijk, J C, Crabbe, H, Rigter
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A model of alcoholism should demonstrate self-administration of alcohol by the animal and a withdrawal syndrome when the animal no longer has access to the drug. A mouse model is described that meets these criteria and enables the induction of "alcoholism" in a large number of animals within a short period of time.
H, Rijk, J C, Crabbe, H, Rigter
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2018
Elastase and chronic cigarette smoke exposure animal models are commonly used to study lung morphologic and functional changes associated with emphysema-like airspace enlargement in various animal species. This chapter describes the rationale for using these two models to study mechanisms of COPD pathogenesis and provides protocols for their ...
Karina A, Serban, Irina, Petrache
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Elastase and chronic cigarette smoke exposure animal models are commonly used to study lung morphologic and functional changes associated with emphysema-like airspace enlargement in various animal species. This chapter describes the rationale for using these two models to study mechanisms of COPD pathogenesis and provides protocols for their ...
Karina A, Serban, Irina, Petrache
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Mouse models of holoprosencephaly
Current Opinion in Neurology, 2003Holoprosencephaly (HPE) is the most common anomaly of forebrain development in humans. The pathogenesis of HPE results in a failure of the brain hemispheres to separate during early development. Here we review experimental models of HPE in which some of the genes known to cause HPE in humans have been disrupted in the mouse.To date, mutations that ...
Monica, Hayhurst, Susan K, McConnell
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