Results 231 to 240 of about 1,627,700 (267)
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Mouse models in oncoimmunology
Nature Reviews Cancer, 2016Fundamental cancer research and the development of efficacious antineoplastic treatments both rely on experimental systems in which the relationship between malignant cells and immune cells can be studied. Mouse models of transplantable, carcinogen-induced or genetically engineered malignancies - each with their specific advantages and difficulties ...
Zitvogel, Laurence +4 more
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Mouse Models of Atherosclerosis
Science, 1996As a species the mouse is highly resistant to atherosclerosis. However, through induced mutations it has been possible to develop lines of mice that are susceptible to this disease. For example, mice that are deficient in apolipoprotein E, a ligand important in lipoprotein clearance, develop atherosclerotic lesions resembling those observed in humans ...
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Journal of Neuro-Oncology, 2010
Meningiomas, although mostly benign, may sometimes present aggressive features and raise issues concerning alternative treatment options besides surgery. In order to gain new insights in meningioma biology and develop alternative treatments, several meningioma mouse models have been engineered during the past two decades. As rodents very rarely develop
Michel, Kalamarides +2 more
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Meningiomas, although mostly benign, may sometimes present aggressive features and raise issues concerning alternative treatment options besides surgery. In order to gain new insights in meningioma biology and develop alternative treatments, several meningioma mouse models have been engineered during the past two decades. As rodents very rarely develop
Michel, Kalamarides +2 more
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Current Protocols in Mouse Biology, 2016
AbstractAllergic asthma is a chronic inflammatory disease of the conducting airways characterized by the presence of allergen‐specific IgE, Th2 cytokine production, eosinophilic airway inflammation, bronchial hyperreactivity, mucus overproduction, and structural changes in the airways.
Nincy, Debeuf +4 more
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AbstractAllergic asthma is a chronic inflammatory disease of the conducting airways characterized by the presence of allergen‐specific IgE, Th2 cytokine production, eosinophilic airway inflammation, bronchial hyperreactivity, mucus overproduction, and structural changes in the airways.
Nincy, Debeuf +4 more
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Journal of Investigative Dermatology
Murine models are vital preclinical and biological tools for studying itch. In this paper, we explore how these models have enhanced our understanding of the mechanisms underlying itch through both acute and chronic itch models. We provide detailed protocols and recommend experimental setups for specific models to guide researchers in conducting itch ...
Daniel, Yassky, Brian S, Kim
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Murine models are vital preclinical and biological tools for studying itch. In this paper, we explore how these models have enhanced our understanding of the mechanisms underlying itch through both acute and chronic itch models. We provide detailed protocols and recommend experimental setups for specific models to guide researchers in conducting itch ...
Daniel, Yassky, Brian S, Kim
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Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 2007
The development of peritoneal dialysis has been paralleled by a growing interest in establishing suitable experimental models to better understand the functional and structural processes operating in the peritoneal membrane. Thus far, most investigations have been performed in rat and rabbit models, with mechanistic insights essentially based on ...
Tomoya, Nishino +2 more
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The development of peritoneal dialysis has been paralleled by a growing interest in establishing suitable experimental models to better understand the functional and structural processes operating in the peritoneal membrane. Thus far, most investigations have been performed in rat and rabbit models, with mechanistic insights essentially based on ...
Tomoya, Nishino +2 more
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Trends in Endocrinology & Metabolism, 2007
The process of implantation, necessary for nearly all viviparous birth, consists of tightly regulated reactions including apposition of the blastocyst, attachment to the uterine epithelium and decidualization of the uterine stroma. In order for implantation to be successful, a reciprocal interaction between an implantation competent blastocyst and ...
Kevin Y, Lee +4 more
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The process of implantation, necessary for nearly all viviparous birth, consists of tightly regulated reactions including apposition of the blastocyst, attachment to the uterine epithelium and decidualization of the uterine stroma. In order for implantation to be successful, a reciprocal interaction between an implantation competent blastocyst and ...
Kevin Y, Lee +4 more
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Thrombosis and Haemostasis, 2002
In the past six years, analysis of numerous murine models, enabled by investigator-designed manipulation of the mouse genome, has gene-rated an explosion of new, and sometimes confounding, data. Mice with complete deficiencies in virtually all the known factors involved in hemostasis have been produced by targeted modification of the genes that encode ...
Kelly A, Hogan +2 more
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In the past six years, analysis of numerous murine models, enabled by investigator-designed manipulation of the mouse genome, has gene-rated an explosion of new, and sometimes confounding, data. Mice with complete deficiencies in virtually all the known factors involved in hemostasis have been produced by targeted modification of the genes that encode ...
Kelly A, Hogan +2 more
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Current Atherosclerosis Reports, 2000
Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystrophy syndrome, offering insights into ...
K, Reue, M, Péterfy
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Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystrophy syndrome, offering insights into ...
K, Reue, M, Péterfy
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The mouse model for atherosclerosis
Trends in Cardiovascular Medicine, 1993The mouse model provides unique tools for studies of the complex environmental and genetic interactions underlying atherosclerosis. In particular, a great variety of inbred strains exhibit variations affecting lipoprotein metabolism, diabetes, obesity, immune regulation, and other processes relevant to the disease.
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