Results 241 to 250 of about 1,832,552 (317)

The Effects of Early Postnatal Alcohol Exposure on Bone Molecular Composition in a Mouse Model. [PDF]

Alcohol Clin Exp Res (Hoboken)
Dursun I, Elibol B, Ustaoglu SG.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A STAT1-Knockout Mouse Model for Chapare Virus Infection and Pathogenesis. [PDF]

Viruses
Monticelli SR, Kuehne AI, Batchelor TG, Richardson JB, Lapoint Z, Williams JL, Coyne SR, Raymond JLW, Zeng X, Stefan CP, Koehler JW, Kugelman JR, Herbert AS.   +12 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Antithrombotic Therapy on Antithrombin Resistance in a Mouse Model. [PDF]

Arterioscler Thromb Vasc Biol
Suzuki N, Suzuki A, Tamura S, Tokumaru S, Notoh H, Takagi A, Suzuki S, Isotani A, Suzuki N, Okamoto S, Kanematsu T, Ikawa M, Hayakawa F, Kiyoi H, Kojima T, Matsushita T.   +15 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Zolpidem restores sleep and decreases amyloid in a mouse model. [PDF]

Alzheimers Dement
Yu L, Yokomizo S, Doan TH, Zhao Q, Ganne A, Balasubramaniam M, Kastanenka KV.   +6 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Establishment of a mouse model of propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis. [PDF]

Animal Model Exp Med
Masuda S, Uchizawa M, Terasaka C, Abe T, Nakamura T, Nishibata Y, Ueda Y, Nakazawa D, Tomaru U, Ishizu A.   +9 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source