Results 31 to 40 of about 2,749,540 (299)

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]

, 2016
Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A., Cunningham, Madeleine E., Fewou, Simon N., Furukawa, Koichi, McGonigal, Rhona, Sankaranarayanan, Sethu, Willison, Hugh J., Yao, Denggao, Yednock, Ted A.   +8 more
core   +2 more sources

Mouse Models of Hepatitis B Virus Infection Comprising Host-Virus Immunologic Interactions

Pathogens, 2014
Hepatitis B virus (HBV) infection is one of the most prevalent infectious diseases associated with various human liver diseases, including acute, fulminant and chronic hepatitis; liver cirrhosis; and hepatocellular carcinoma.
Tadashi Inuzuka, Ken Takahashi, Tsutomu Chiba, Hiroyuki Marusawa   +3 more
doaj   +1 more source

A fast, simple, and cost-effective method of expanding patient-derived xenograft mouse models of pancreatic ductal adenocarcinoma

Journal of Translational Medicine, 2020
Background Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original malignancies including preserved tumor heterogeneity, lineage hierarchy, and tumor ...
Zhenyang Liu, Michael Ho-Young Ahn, Tomohiro Kurokawa, Amy Ly, Gong Zhang, Fuyou Wang, Teppei Yamada, Ananthan Sadagopan, Jane Cheng, Cristina R. Ferrone, Andrew S. Liss, Kim C. Honselmann, Gregory R. Wojtkiewicz, Soldano Ferrone, Xinhui Wang   +14 more
doaj   +1 more source

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease [PDF]

, 2019
Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Burris, Thomas P, Farr, Susan A, Kermath, Bailey A, Morley, John E, Musiek, Erik S, Niehoff, Michael, Roby, Deborah A, Ruiz, Fernanda, Voorhees, Jaymie R, Zhang, Jinsong   +9 more
core   +3 more sources

Construction and characterization of an infectious cDNA clone of coxsackievirus A 10

Virology Journal, 2019
Background Coxsackievirus A10 (CA10) constitutes one of the four major pathogens causing hand, foot and mouth disease in infants. Infectious clones are of great importance for studying viral gene functions and pathogenic mechanism.
Qiliang Liu, Hanliang Dan, Xiaoping Zhao, Huoying Chen, Yongbei Chen, Ning Zhang, Zhijing Mo, Hongbo Liu   +7 more
doaj   +1 more source

Endometriosis in the Mouse: Challenges and Progress Toward a ‘Best Fit’ Murine Model

Frontiers in Physiology, 2022
Endometriosis is a prevalent gynecologic condition associated with pelvic pain and infertility characterized by the implantation and growth of endometrial tissue displaced into the pelvis via retrograde menstruation.
Katherine A. Burns, Amelia M. Pearson, Jessica L. Slack, Elaine D. Por, Alicia N. Scribner, Nazmin A. Eti, Richard O. Burney, Richard O. Burney   +7 more
doaj   +1 more source

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis [PDF]

, 2016
Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted ...
Boel, Annekatrien, Colpaert, Robin, Creytens, David, Deforce, Dieter, Dimitrakopoulou, Dionysia, Haustraete, Jurgen, L, J, Lepez, Trees, Naert, Thomas, Steyaert, Wouter, Van Nieuwenhuysen, Tom, Vleminckx, Kris, Willaert, Andy   +12 more
core   +2 more sources

The role of mouse models in colorectal cancer research—The need and the importance of the orthotopic models

Animal Models and Experimental Medicine, 2020
Colorectal cancer is a worldwide health burden, with high incidence and mortality, especially in the advanced stages of the disease. Preclinical models are very important and valuable to discover and validate early and specific biomarkers as well as new ...
Rui C. Oliveira, Ana Margarida Abrantes, José Guilherme Tralhão, Maria Filomena Botelho   +3 more
doaj   +1 more source

A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype

Asthma Research and Practice, 2022
Background Asthma is a heterogeneous disease; therefore, biomarkers that can assist in the identification of subtypes and direct therapy are highly desirable. Asthma is a chronic inflammatory disease that leads to changes in the extracellular matrix (ECM)
Sarah Rank Rønnow, Jannie Marie Bülow Sand, Line Mærsk Staunstrup, Thomas Bahmer, Michael Wegmann, Lars Lunding, Janette Burgess, Klaus Rabe, Grith Lykke Sorensen, Oliver Fuchs, Erika V. Mutius, Gesine Hansen, Matthias Volkmar Kopp, Morten Karsdal, Diana Julie Leeming, Markus Weckmann, the ALLIANCE Study Group as part of the German Center of Lung Research (DZL)   +16 more
doaj   +1 more source

Developmental aspect of decidual patterning

Reproductive and Developmental Medicine, 2017
In clinical practice, early pregnancy loss has afflicted approximately 15%–25% women of reproductive age worldwide, which is partially attributed to defects associated with the endometrium.
Chan Zhou, Hai-Li Bao, Shuang-Bo Kong, Jin-Hua Lu, Hai-Bin Wang   +4 more
doaj   +1 more source