Results 31 to 40 of about 1,587,863 (170)
Preclinical Ultrasound Imaging—A Review of Techniques and Imaging Applications
Frontiers in Physics, 2020 Ultrasound imaging is a well-established clinical imaging technique providing real-time, quantitative anatomical and physiological information in humans.
Carmel M. Moran, Adrian J. W. Thomson
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FASEB BioAdvances, 2019 Inflammatory bowel diseases (IBD: Crohn's disease and ulcerative colitis) are becoming common around the world without a cure. Animal models of colitis have become instrumental in IBD research.
Savini Lanka Britto +2 more
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Translational Oncology, 2022 Melanoma is an aggressive skin cancer that metastasizes to other organs. While immune checkpoint blockade with anti-PD-1 has transformed the treatment of advanced melanoma, many melanoma patients fail to respond to anti-PD-1 therapy or develop acquired ...
Anngela C. Adams +11 more
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Mouse Model of Tuberculosis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 The mouse provides a tool with which to probe the complex interaction between the mammalian immune system and the slow-growing, inflammatory, and persistent bacterium, Mycobacterium tuberculosis (Mtb). Simple mouse models using genetic deletion or antibody inhibition have identified causal connections between specific components of the immune response ...
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Mouse models and mouse supermodels
EMBO Molecular Medicine, 2010 Varnat et al, EMBO Mol Med, 1, 338–351, report that Hedgehog (HH) signalling is essential for growth of human colon carcinoma (CC) (Varnat et al, 2009). In the accompanying Closeup article (Gulino et al, 2009) state that while participation of the HH pathway in CC has been controversial because of conflicting and contradictory data (Varnat et al, 2009)
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Identification of genetic elements in metabolism by high-throughput mouse phenotyping
Nature Communications, 2018 The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory ...
Jan Rozman +64 more
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Genetics and Molecular Biology, 2005 The Paralysé mutation is a spontaneous neuromuscular mutation, first observed in 1980 at the Pasteur Institute, which is transmitted by the autosomal recessive par allele.
Lino Silva Neto +3 more
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Aging Cell, 2012 AbstractThe A‐ and B‐type lamins are nuclear intermediate filament proteins in eukaryotic cells with a broad range of functions, including the organization of nuclear architecture and interaction with proteins in many cellular functions. Over 180 disease‐causing mutations, termed ‘laminopathies,’ have been mapped throughout LMNA, the gene for A‐type ...
Haoyue, Zhang +2 more
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Mouse Models of Psoriasis [PDF]
Journal of Investigative Dermatology, 2007 Psoriasis is a T-cell-mediated chronic inflammatory skin disease believed to be of autoimmune nature that can be triggered or worsened by streptococcal throat infections. In addition to conventional chronic inflammatory changes, psoriasis is characterized by complex and striking alterations in epidermal growth and differentiation.
Gudjonsson, Johann E. +4 more
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Cytomegalovirus Infection: Mouse Model [PDF]
Current Protocols in Immunology, 2018 AbstractThis unit describes procedures for infecting newborn and adult mice with murine cytomegalovirus (MCMV). Methods are included for propagating MCMV in cell cultures and for preparing a more virulent form of MCMV from salivary glands of infected mice. A plaque assay is provided for determining MCMV titers of infected tissues or virus stocks. Also,
Brizić, Ilija +4 more
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