Results 51 to 60 of about 1,587,863 (170)

A decade progress in the phenotyping of AppNL-G-F knock-in mouse model of Alzheimer’s disease

Neuroscience Research
Numerous mouse models of Alzheimer’s disease (AD) have developed since the discovery of mutations causing familial AD. These models successfully recapitulate the progressive amyloid pathology over time, thus serving as indispensable tools for improving ...
Tatsuya Manabe, Takashi Saito
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A simple mouse model of pericardial adhesions

Journal of Cardiothoracic Surgery, 2019
Background Postoperative pericardial adhesions are considered a risk factor for redo cardiac surgery. Several large- and medium-size animal models of pericardial adhesions have been reported, but small animal models for investigating the development of ...
Ai Kojima, Tomohisa Sakaue, Mikio Okazaki, Fumiaki Shikata, Mie Kurata, Yuuki Imai, Hirotomo Nakaoka, Junya Masumoto, Shunji Uchita, Hironori Izutani   +9 more
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Resveratrol Ameliorates Imiquimod-Induced Psoriasis-Like Mouse Model via Reducing Macrophage Infiltration and Inhibiting Glycolysis

Journal of Inflammation Research, 2023
Yazhuo Wang,1,2 Cong Qi,1,2 Fang Feng,3 Xueqing Hu,3 Ning Zhao,1,2 Jingxia Zhao,1 Tingting Di,1 Yujiao Meng,1 Danyang Yang,1,2 Haoyue Zhu,1,2 Xiawei Zhang,1,2 Ping Li,1 Yan Wang1 1Beijing Hospital of Traditional Chinese Medicine, Capital Medical ...
Wang Y, Qi C, Feng F, Hu X, Zhao N, Zhao J, Di T, Meng Y, Yang D, Zhu H, Zhang X, Li P, Wang Y   +12 more
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CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model

Laboratory Animal Research, 2018
Placenta specific 8 (PLAC8, also known as ONZIN) is a multi-functional protein that is highly expressed in the intestine, lung, spleen, and innate immune cells, and is involved in various diseases, including cancers, obesity, and innate immune deficiency.
HyunJeong Lee, Joo-Il Kim, Jin-Sung Park, Jae-il Roh, Jaehoon Lee, Byeong-Cheol Kang, Han-Woong Lee   +6 more
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Genetically engineered mouse model of pleomorphic liposarcoma: Immunophenotyping and histologic characterization

Neoplasia: An International Journal for Oncology Research
Introduction: Pleomorphic liposarcoma is a rare and aggressive subset of soft-tissue sarcomas with a high mortality burden. Local treatment largely consists of radiation therapy and wide surgical resection, but options for systemic therapy in the setting
Jeffrey Mark Brown, Rahi Patel, Kyllie Smith-Fry, Michael Ward, Trudy Oliver, Kevin B Jones   +5 more
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Mouse Models of Sepsis

Current Protocols
AbstractHuman sepsis is a complex disease that manifests with a diverse range of phenotypes and inherent variability among individuals, making it hard to develop a comprehensive animal model. Despite this difficulty, numerous models have been developed that capture many key aspects of human sepsis. The robustness of these models is vital for conducting
Shravan Kumar Kannan, Caleb Y. Kim, Mohammad Heidarian, Roger R. Berton, Isaac J. Jensen, Thomas S. Griffith, Vladimir P. Badovinac   +6 more
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Downregulation of HNRNPK in human cancer cells inhibits lung metastasis

Animal Models and Experimental Medicine, 2019
Background Lung cancer frequently occurs in the clinic, leading to poor prognosis and high mortality. Markers for early diagnosis of lung cancer are scarce, and further potential therapeutic targets are also urgently needed.
Mengyuan Li, Wenlong Zhang, Xingjiu Yang, Hongfei Liu, Lin Cao, Weisha Li, Le Wang, Guoxin Zhang, Ran Gao   +8 more
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Molecular Imaging of Inflammation in a Mouse Model of Atherosclerosis Using a Zirconium-89-Labeled Probe

International Journal of Nanomedicine, 2020
Mona Ahmed,1,2 Tetyana Tegnebratt,3,4 Thuy A Tran,3,4 Li Lu,3,4 Peter Damberg,3 Anton Gisterå,5 Laura Tarnawski,5 Dianna Bone,1,6 Ulf Hedin,1,7 Per Eriksson,5 Staffan Holmin,3,8 Björn Gustafsson,1,* Kenneth Caidahl1,6,9,10,* 1Department of ...
Ahmed M, Tegnebratt T, Tran TA, Lu L, Damberg P, Gisterå A, Tarnawski L, Bone D, Hedin U, Eriksson P, Holmin S, Gustafsson B, Caidahl K   +12 more
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Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis

Drug Design, Development and Therapy, 2016
Michael R Preusch,1 Jonas Rusnak,1 Kathrin Staudacher,2 Carolin Mogler,3 Lorenz Uhlmann,4 Philipp Sievers,1 Florian Bea,1 Hugo A Katus,1 Erwin Blessing,1 Ingo Staudacher1 1Department of Internal Medicine III, 2Department of Neonatology, 3Department of ...
Preusch MR, Rusnak J, Staudacher K, Mogler C, Uhlmann L, Sievers P, Bea F, Katus HA, Blessing E, Staudacher I   +9 more
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Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression

Molecular Oncology
Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems.
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas deLaat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick   +14 more
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