Results 71 to 80 of about 10,046,523 (395)

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Assessment of pharmacists' oral health advice to clients without prescription using “By Proxy” method

Journal of Indian Association of Public Health Dentistry, 2016
Background: In India, people commonly approach pharmacies rather than health professionals for their common ailments including oral health problems. Aim: To assess the type of medication and advice to clients without prescription provided for common oral
Savithra Prakash, Shrudha Potdar, Nagesh Lakshminarayan   +2 more
doaj   +1 more source

Emerging Coxsackievirus A6 Causing Hand, Foot and Mouth Disease, Vietnam

Emerging Infectious Diseases, 2018
Hand, foot and mouth disease (HFMD) is a major public health issue in Asia and has global pandemic potential. Coxsackievirus A6 (CV-A6) was detected in 514/2,230 (23%) of HFMD patients admitted to 3 major hospitals in southern Vietnam during 2011–2015 ...
N. T. Anh, L. Nhu, H. Van, N. Hong, T. T. Thanh, V. Hang, N. Ny, L. A. Nguyet, T. Phuong, L. Nhan, N. T. Hung, T. H. Khanh, H. M. Tuan, H. Viet, Nguyen Tran Nam, D. C. Viet, P. Qui, B. Wills, Sarawathy Sabanathan, N. Chau, L. Thwaites, H. Rogier van Doorn, G. Thwaites, M. Rabaa, Le Van Tan   +24 more
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

The "Canone Inverso": when tobacco was not so bad. A Look Back at the Primordial Debate on the tobacco effects in the Occupational Medicine [PDF]

, 2018
AIM: The article provides an overview on the beginning and evolutions of medical observations on tobacco induced diseases between Eighteenth and Nineteenth century.
Gulino, Matteo, Iorio, Silvia, Licata, Marta, Marinozzi, Silvia   +3 more
core   +1 more source

Emerging Enteroviruses Causing Hand, Foot and Mouth Disease, China, 2010–2016

Emerging Infectious Diseases, 2018
Coxsackievirus A6 emerged as one of the predominant causative agents of hand, foot and mouth disease epidemics in many provinces of China in 2013 and 2015.
Yu Li, Z. Chang, Peng Wu, Q. Liao, Fengfeng Liu, Yaming Zheng, L. Luo, Yonghong Zhou, Qi Chen, Shuan-bao Yu, Chun Guo, Zhenhua Chen, L. Long, Shanlu Zhao, Bingyi Yang, Hongjie Yu, B. Cowling   +16 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Palliative care assessment of dry mouth: what matters most to patients with advanced disease?

Supportive Care in Cancer, 2019
Purpose Dry mouth is a highly prevalent and significant symptom in patients with advanced progressive diseases. It is a poorly understood area of research, and currently, there is no standardised outcome measure or assessment tool for dry mouth.
M. Fleming, C. Craigs, M. Bennett
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Correlação entre os diagnósticos citopatológicos e histopatológicos das lesões da mucosa oral após a punção aspirativa por agulha fina

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Fazer um estudo retrospectivo, correlacionando os diagnósticos citopatológicos obtidos por punção aspirativa por agulha fina (PAAF) com os diagnósticos histopatológicos de lesões da região bucomaxilofacial, de pacientes que foram atendidos no ...
Tatiana Ferreira Robaina, Antonio Carlos de Azeredo Coutinho, Carla Peixoto Valladares, Eliane Pedra Dias, Simone de Queiroz Chaves Lourenço   +4 more
doaj   +1 more source