Results 41 to 50 of about 2,928,215 (296)

Do Disorders of Movement Cause Movement Disorders and Dementia? [PDF]

Neuron, 2003
Neurons require long-distance microtubule-based transport systems to ferry vital cellular cargoes and signals between cell bodies and axonal or dendritic terminals. Considerable progress has been made on developing a molecular understanding of these processes and how they are integrated into normal neuronal functions.
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

EMPOWER-PD: Evaluation of an 8-Week Co-Designed Self-Management Program in People With Parkinson’s Disease and Their Caregivers: An Intervention Study With Long-Term Follow-Up

Parkinson's Disease
Empowerment and implementation of self-management strategies are vital components in the future care of chronic, neurological patient groups, including people with Parkinson’s disease (PD).
Trine Hørmann Thomsen, Sara Lungby Skovbølling, Maria Brønden, Jakob Frederiksen, Maja Hedegaard Lauritzen, Marcus Dalsgaard, Bo Biering-Sørensen   +6 more
doaj   +1 more source

Therapeutic Approach to Primary Tic Disorders and Associated Psychiatric Comorbidities

Brain Sciences
Background/Objectives: The treatment of tics and psychiatric comorbidities is crucial when they affect the patient’s well-being and relationships. However, the optimal pharmacological treatment (PT) tailored to each patient’s phenotype remains unclear ...
Irene Berzosa-Gonzalez, Saul Martinez-Horta, Jesus Pérez-Pérez, Jaime Kulisevsky, Javier Pagonabarraga   +4 more
doaj   +1 more source

Efficacy of faecal microbiota transplantation in patients with progressive supranuclear palsy-Richardson's syndrome: a phase 2, single centre, randomised clinical trialResearch in context

EClinicalMedicine, 2023
Summary: Background: Faecal microbiota transplantation (FMT) has demonstrated efficacy in treating gastrointestinal (GI) diseases, such as Clostridium difficile infection (CDI) and inflammatory bowel disease (IBD).
Haiyan Tian, Jiuqi Wang, Renyi Feng, Rui Zhang, Han Liu, Chi Qin, Lin Meng, Yongkang Chen, Yu Fu, Dongxiao Liang, Xin Yuan, Yanping Zhai, Qingyong Zhu, Lingjing Jin, Junfang Teng, Xuebing Ding, Xuejing Wang   +16 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Eye movement sequences during simple versus complex information processing of scenes in autism spectrum disorder [PDF]

, 2011
Minshew and Goldstein (1998) postulated that autism spectrum disorder (ASD) is a disorder of complex information processing. The current study was designed to investigate this hypothesis.
Monica Castelhano, Benson, Valerie, Sheena K. Au-Yeung, Valerie Benson, Keith Rayner, Au-Yeung, Sheena K., Au-Yeung, Sheena K., Castelhano, Monica, Rayner, Keith   +8 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Abbreviated MDS-UPDRS for Remote Monitoring in PD Identified Using Exhaustive Computational Search

Parkinson's Disease, 2022
Background. The Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) comprises 50 items, consisting of historical questions and motor ratings, typically taking around 30 minutes to complete.
Gareth Morinan, Robert A. Hauser, Anette Schrag, Jingxuan Tang, Jonathan O’Keeffe, null MDS-NMS Scale Development Study Group   +5 more
doaj   +1 more source