Results 101 to 110 of about 974,805 (252)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Long-Term Real-World Experience with Safinamide in Patients with Parkinson’s Disease

Brain Sciences
Introduction: Randomized clinical trials should be complemented with data from real-world studies. We report our long-term experience with safinamide in a movement disorders unit.
Anna Planas-Ballvé, Núria Caballol Pons, Alejandro Peral Quirós, Isabel Gómez Ruiz, Marta Balagué Marmaña, Alexander J. Velázquez Ballester, Dolors Lozano Moreno, Asunción Ávila Rivera   +7 more
doaj   +1 more source

Brain–computer interface game applications for combined neurofeedback and biofeedback treatment for children on the autism spectrum [PDF]

, 2014
Individuals with Autism Spectrum Disorder (ASD) show deficits in social and communicative skills, including imitation, empathy, and shared attention, as well as restricted interests and repetitive patterns of behaviors.
Friedrich, Elisabeth V. C., Lim, Theodore, Louchart, Sandy, Pineda, Jaime A., Sivanathan, Aparajithan, Suttie, Neil   +5 more
core   +4 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Blended phenotype of TECPR2‐associated hereditary sensory‐autonomic neuropathy and Temple syndrome

Annals of Clinical and Translational Neurology
Uniparental isodisomy (UPiD) can cause mixed phenotypes of imprinting disorders and autosomal‐recessive diseases. We present the case of a 3‐year‐old male with a blended phenotype of TECPR2‐related hereditary sensory and autonomic neuropathy (HSAN9) and ...
Umar Zubair, Kathryn Yang, Luca Schierbaum, Amy Tam, Nicole Battaglia, Joshua Rong, Vicente Quiroz, Darius Ebrahimi‐Fakhari   +7 more
doaj   +1 more source

A translational approach to capture gait signatures of neurological disorders in mice and humans

Scientific Reports, 2017
A method for capturing gait signatures in neurological conditions that allows comparison of human gait with animal models would be of great value in translational research.
Lauren Broom, Brian A. Ellison, Audrey Worley, Lara Wagenaar, Elina Sörberg, Christine Ashton, David A. Bennett, Aron S. Buchman, Clifford B. Saper, Ludy C. Shih, Jeffrey M. Hausdorff, Veronique G. VanderHorst   +11 more
doaj   +1 more source

Idiopathic head tremor in english bulldogs [PDF]

, 2014
Idiopathic head tremor (IHT) syndrome is a recognized but poorly characterized movement disorder in English bulldogs (EBs). The data analyzed were collected via a detailed online questionnaire and video recordings.
Bagley, Deuschl, Forman, Gill, Harcourt-Brown, Herrtage, Jokinen, Lahunta, Lahunta, Leegwater-Kim, Louis, Meyers, Nakahata, Packer, Penderis, Ramsey, Teive, Tremor, myoclonus, focal dystonias, and tics, Wolf, Woods   +19 more
core   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Parameter selection drives electrophysiological responses to adaptive deep brain stimulation in Parkinson’s disease

Brain Stimulation, 2023
Johannes Leon Busch, Jonathan Kaplan, Jeroen Habets, Lucia Feldmann, Jan Roediger, Richard Köhler, Timon Merk, Katharina Faust, Gerd-Helge Schneider, Wolf-Julian Neumann, Andrea Kühn   +10 more
doaj   +1 more source