Results 81 to 90 of about 3,376,946 (257)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Disorders of the Oral Cavity in Parkinson’s Disease and Parkinsonian Syndromes
Parkinson's Disease, 2015 Awareness of nonmotor symptoms of Parkinson’s disease is growing during the last decade. Among these, oral cavity disorders are, although prevalent, often neglected by the patients, their caregivers, and physicians.
Yair Zlotnik +4 more
doaj +1 more source
, 2014 Objective: This study was carried out to examine the effect of the Subthalamic nucleus deep brain stimulation (STN-DBS) surgery on the characteristics of the gait.
Ünal, Ayşe +5 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Heterozygous variants in AP4S1 are not associated with a neurological phenotype
Annals of Clinical and Translational NeurologyBiallelic loss‐of‐function variants in AP4S1 cause childhood‐onset hereditary spastic paraplegia. A recent report suggested that heterozygous AP4S1 variants lead to a syndrome of lower limb spasticity and dysregulation of sphincter function.
Vicente Quiroz +9 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Rapid eye movement sleep behavior disorder: modern concept and Parkinson’s disease correlation [PDF]
Анналы клинической и экспериментальной неврологииThis review describes the association between rapid eye movement (REM) sleep behavior disorder (RBD) and synucleinopathies, primarily Parkinson's disease.
Diana M. Khasanova +3 more
doaj +1 more source
The Parasomnias and other sleep-related movement disorders
, 2010 Parasomnias and other sleep-related movement disorders provides scientific and clinical information on abnormal movement disorders during sleep for all health care workers interested in disorders of ...
M. J. Thorpy, PLAZZI, GIUSEPPE
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
npj Parkinson's DiseaseAccurate subthalamic beta activity could guide deep brain stimulation programming in Parkinson’s disease, but bipolar recordings complicate contact selection. In 39 patients, we validated three methods to estimate pseudo-monopolar beta power.
Jennifer K. Behnke +14 more
doaj +1 more source