Results 71 to 80 of about 3,254,927 (309)

Deciphering the effects of STN DBS on neuropsychiatric fluctuations in Parkinson’s disease

npj Parkinson's Disease
The impact of subthalamic nucleus (STN) deep brain stimulation (DBS) on neuropsychiatric fluctuations in Parkinson´s disease (PD) remains unclear. The Neuropsychiatric Fluctuations Scale (NFS) can help to fill this gap, directly measuring fluctuations ...
Mari Muldmaa, Emmanuelle Schmitt, Roberto Infante, Andrea Kistner, Valérie Fraix, Anna Castrioto, Sara Meoni, Pierre Pélissier, Bettina Debû, Elena Moro   +9 more
doaj   +1 more source

Takayasu's Arteritis in a Patient with Sydenham's Chorea: Is There an Association?

Tremor and Other Hyperkinetic Movements, 2012
Background: Takayasu's arteritis (TA) has been associated with many conditions. Herein described is a case of TA in a patient with rheumatic fever complicated with Sydenham's chorea.Case Report: A 17-year-old female presented at age 6 with ...
Thiago C. Vale, Ricardo O. Maciel, Débora P. Maia, Rogério Beato, Francisco Cardoso   +4 more
doaj   +1 more source

Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington’s disease

Annals of Clinical and Translational Neurology, 2021
Female Huntington’s disease (HD) patients have consistently shown a faster clinical worsening than male, but the underlying mechanisms responsible for this observation remain unknown.
Frederic Sampedro, Saul Martinez‐Horta, Jesús Pérez‐Pérez, Rocio Perez‐Gonzalez, Andrea Horta‐Barba, Antonia Campolongo, Ignacio Aracil‐Bolaños, Beatriz Gomez‐Anson, Jaume Kulisevsky   +8 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Untangling neurodevelopmental disorders in the adulthood: a movement disorder is the clue

Orphanet Journal of Rare Diseases, 2022
Background The genetic landscape of neurodevelopmental disorders is constantly expanding and children with early-onset neurological phenotypes increasingly receive a genetic diagnosis. Nonetheless, the awareness of the chronic course of these conditions,
Elisabetta Indelicato, Michael Zech, Matthias Amprosi, Sylvia Boesch   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Functional movement disorders

Revue Neurologique, 2020
Functional movement disorders (FMD) represent a complex and disabling entity characterized by a broad range of clinical symptoms not explained by a classical neurological disease. In 2013, the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) added a clinical criterion based on incongruence and inconsistency, supported by recent literature ...
Galli, S., Béreau, M., Magnin, E., Moulin, T., Aybek, S.   +4 more
openaire   +5 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Definition and classification of hyperkinetic movements in childhood [PDF]

, 2010
Hyperkinetic movements are unwanted or excess movements that are frequently seen in children with neurologic disorders. They are an important clinical finding with significant implications for diagnosis and treatment.
Lehman, Rebecca K., Hilla Ben-Pazi, Michaels, Margaret Barry, Gilbert, Donald L., Butler, Erin E., Mark Hallett, Malanga, C. J., Eileen Fowler, Barbara Kornblau, Francisco Valero-Cuevas, Hans Forssberg, Krosschell, Kristin J., Alter, Katharine, MacKinnon, Colum, C. J. Malanga, Rose, Jessica, Mesterman, Ronit, Donald L. Gilbert, Swoboda, Kathy J., Valero-Cuevas, Francisco, Toni S. Pearson, Daofen Chen, Kristin J. Krosschell, Dayanidhi, Sudarshan, Jonathan W. Mink, Kornblau, Barbara, Kathy J. Swoboda, Katharine Alter, Jinnah, H. A., Dagmar Sternad, Sharon L. Gorman, Margaret Barry Michaels, Erin E. Butler, Jessica Rose, Anthony E. Lang, Terence D. Sanger, Mark E. Gormley, Gorman, Sharon L., Sudarshan Dayanidhi, Robert Chen, Lang, Anthony E., Mink, Jonathan W., Darcy L. Fehlings, Forssberg, Hans, Sternad, Dagmar, Barry S. Russman, H. A. Jinnah, Gormley, Mark E., Sanger, Terence D., Colum MacKinnon, Chen, Daofen, Harvey S. Singer, Abigail Collins, Ronit Mesterman, Russman, Barry S., Fowler, Eileen, Pearson, Toni S., Rebecca K. Lehman, Hallett, Mark, Singer, Harvey S., Ben-Pazi, Hilla, Collins, Abigail, Fehlings, Darcy L., Chen, Robert, Fehlings, DL, Hallett, M, Alter, K, Lang, AE, Sanger, TD, Ben-Pazi, H, Butler, EE, Chen, D, Singer, HS, Mink, JW   +73 more
core   +1 more source