Results 51 to 60 of about 3,376,946 (257)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Interaction- and asymmetry-aware facial blendshape analysis for objective quantification of Parkinsonian hypomimia

npj Parkinson's Disease
Reduced facial expressivity (hypomimia) is an early motor feature of Parkinson’s disease (PD), yet its assessment still relies on subjective, coarse-grained clinical scales.
Berkan Koyak, Timo Menzel, Martin Rodemann, Guido Hennes, Annika Spottke, Eva Saxler, Janis Bedarf, Jennifer Faber, Michael Sommerauer, Patrick Weydt, Martin Reuter, Mario Botsch, Ullrich Wuellner, N. Ahmad Aziz   +13 more
doaj   +1 more source

Comparable Botulinum Toxin Outcomes between Primary and Secondary Blepharospasm: A Retrospective Analysis

Tremor and Other Hyperkinetic Movements, 2014
Background: Blepharospasm is a focal cranial dystonia, which could be idiopathic in origin or secondary to an underlying disorder that commonly impairs quality of life.
Daniel Martinez-Ramirez, Juan C. Giugni, Erin Hastings, Aparna W. Shukla, Irene A. Malaty, Michael S. Okun, Ramon L. Rodriguez   +6 more
doaj   +1 more source

Transient movement disorders and multiple sclerosis

, 2002
Movement disorders associated with multiple sclerosis (MS) are uncommon, except for tremor. We report two patients with relapsing-remitting MS, who developed either dystonia or chorea during clinical exacerbation of their MS.
Sheremata, William A, Minagar, Alireza, Weiner, William J   +2 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Takayasu's Arteritis in a Patient with Sydenham's Chorea: Is There an Association?

Tremor and Other Hyperkinetic Movements, 2012
Background: Takayasu's arteritis (TA) has been associated with many conditions. Herein described is a case of TA in a patient with rheumatic fever complicated with Sydenham's chorea.Case Report: A 17-year-old female presented at age 6 with ...
Thiago C. Vale, Ricardo O. Maciel, Débora P. Maia, Rogério Beato, Francisco Cardoso   +4 more
doaj   +1 more source

Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington’s disease

Annals of Clinical and Translational Neurology, 2021
Female Huntington’s disease (HD) patients have consistently shown a faster clinical worsening than male, but the underlying mechanisms responsible for this observation remain unknown.
Frederic Sampedro, Saul Martinez‐Horta, Jesús Pérez‐Pérez, Rocio Perez‐Gonzalez, Andrea Horta‐Barba, Antonia Campolongo, Ignacio Aracil‐Bolaños, Beatriz Gomez‐Anson, Jaume Kulisevsky   +8 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co-Occurring Hyperkinetic Movement Disorders. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Cif L, Demailly D, Horvàth GA, Ortigoza Escobar JD, Dorison N, Castro Jiménez M, Hubsch CA, Wirth T, Hariz GM, Huby S, Dornadic M, Souei Z, Mushhood Ur Rehman M, Hemm S, Boulaymen M, Moraud EM, Bloch J, Vasques X.   +17 more
europepmc   +2 more sources

Psychogenic movement disorders in two children

, 2003
Two schoolboys with diagnostic criteria for psychogenic movement disorder (PMD) are described: one with bizarre tremor of the right hand and a very slow and cautious gait, another with exaggerated trunk sway and collapses during standing and walking. (C)
Yalcinkaya, C, Ozekmekci, S, Ekinci, B, Apaydin, H   +3 more
core   +1 more source