Results 31 to 40 of about 3,376,946 (257)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Chiropractic management of dominating one-sided pelvic girdle pain in pregnant women; a randomized controlled trial

BMC Pregnancy and Childbirth, 2017
Background The aim of this study was to investigate the outcome of chiropractic management for a subgroup of pregnant women with dominating one-sided pelvic girdle pain (PGP).
Anne Marie Gausel, Inger Kjærmann, Stefan Malmqvist, Knut Andersen, Ingvild Dalen, Jan Petter Larsen, Inger Økland   +6 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Method of Tremor Levodopa Responsiveness Assessment and Its Correlation With Clinical Factors in Parkinson’s Disease: Outcomes of the Acute Levodopa Challenge Test

Parkinson's Disease
Conclusions: The aLR, rather than the %LR, is a more effective assessment method for evaluating the efficacy of levodopa for treating tremors in PD.
Fangfei Li, Shaosong Xing, Yusha Cui, Lingyan Ma, Rui Yan, Genliang Liu, Tao Feng   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Abnormal Eye Movements in Parkinsonism and Movement Disorders [PDF]

, 2019
Abnormal eye movements are commonly observed in movement disorders. Ocular motility examination should include bedside evaluation and laboratory recording of ocular misalignment, involuntary eye movements, including nystagmus and saccadic intrusions ...
Ileok Jung, Ji-Soo Kim
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The severity progression of non-motor symptoms in Parkinson’s disease: a 6-year longitudinal study in Taiwanese patients

Scientific Reports, 2021
Nonmotor symptoms (NMSs) cause major burden in patients with Parkinson’s disease (PD). Previous NMSs progression studies mostly focused on the prevalence. We conducted a longitudinal study to identify the progression pattern by the severity.
Yi-Chieh Chen, Rou-Shayn Chen, Yi-Hsin Weng, Ying-Zu Huang, Chiung Chu Chen, June Hung, Yi-Ying Lin   +6 more
doaj   +1 more source

Definition and classification of hyperkinetic movements in childhood [PDF]

, 2010
Hyperkinetic movements are unwanted or excess movements that are frequently seen in children with neurologic disorders. They are an important clinical finding with significant implications for diagnosis and treatment.
Lehman, Rebecca K., Hilla Ben-Pazi, Michaels, Margaret Barry, Gilbert, Donald L., Butler, Erin E., Mark Hallett, Malanga, C. J., Eileen Fowler, Barbara Kornblau, Francisco Valero-Cuevas, Hans Forssberg, Krosschell, Kristin J., Alter, Katharine, MacKinnon, Colum, C. J. Malanga, Rose, Jessica, Mesterman, Ronit, Donald L. Gilbert, Swoboda, Kathy J., Valero-Cuevas, Francisco, Toni S. Pearson, Daofen Chen, Kristin J. Krosschell, Dayanidhi, Sudarshan, Jonathan W. Mink, Kornblau, Barbara, Kathy J. Swoboda, Katharine Alter, Jinnah, H. A., Dagmar Sternad, Sharon L. Gorman, Margaret Barry Michaels, Erin E. Butler, Jessica Rose, Anthony E. Lang, Terence D. Sanger, Mark E. Gormley, Gorman, Sharon L., Sudarshan Dayanidhi, Robert Chen, Lang, Anthony E., Mink, Jonathan W., Darcy L. Fehlings, Forssberg, Hans, Sternad, Dagmar, Barry S. Russman, H. A. Jinnah, Gormley, Mark E., Sanger, Terence D., Colum MacKinnon, Chen, Daofen, Harvey S. Singer, Abigail Collins, Ronit Mesterman, Russman, Barry S., Fowler, Eileen, Pearson, Toni S., Rebecca K. Lehman, Hallett, Mark, Singer, Harvey S., Ben-Pazi, Hilla, Collins, Abigail, Fehlings, Darcy L., Chen, Robert, Fehlings, DL, Hallett, M, Alter, K, Lang, AE, Sanger, TD, Ben-Pazi, H, Butler, EE, Chen, D, Singer, HS, Mink, JW   +73 more
core   +1 more source