Results 41 to 50 of about 3,376,946 (257)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients

npj Parkinson's Disease
Alpha-synuclein (αS) aggregation is a widely regarded hallmark of Parkinson’s disease (PD) and can be detected through synuclein amplification assays (SAA).
Amgad Droby, Avital Yoffe-Vasiliev, Daniel Atias, Kyle B. Fraser, Omar S. Mabrouk, Nurit Omer, Anat Bar-Shira, Mali Gana-Weisz, Orly Goldstein, Moran Artzi, Dafna Ben Bashat, Roy N. Alcalay, Avi Orr-Urtreger, Julia C. Shirvan, Jesse M. Cedarbaum, Nir Giladi, Anat Mirelman, Avner Thaler   +17 more
doaj   +1 more source

Generalized Dystonia and Paroxysmal Dystonic Attacks due to a Novel ATP1A3 Variant

Tremor and Other Hyperkinetic Movements, 2019
Background: Paroxysmal movement disorders are a heterogeneous group of neurological diseases, better understood in recent years thanks to widely available genetic testing.
Carlos Zúñiga-Ramírez, Mirelle Kramis-Hollands, Rodrigo Mercado-Pimentel, Héctor Alberto González-Usigli, Michel Sáenz-Farret, Alberto Soto-Escageda, Alfonso Fasano   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Chronic adaptive deep brain stimulation for Parkinson’s disease: clinical outcomes and programming strategies

npj Parkinson's Disease
Adaptive deep brain stimulation (DBS) dynamically adjusts stimulation amplitude based on neurophysiological feedback and may alleviate residual motor fluctuations in patients with Parkinson’s disease.
Johannes L. Busch, Jonathan Kaplan, Jennifer K. Behnke, Victoria S. Witzig, Luisa Drescher, Jeroen G. V. Habets, Andrea A. Kühn   +6 more
doaj   +1 more source

Brittle Dyskinesia Following STN but not GPi Deep Brain Stimulation

Tremor and Other Hyperkinetic Movements, 2014
Background: The aim was to describe the prevalence and characteristics of difficult to manage dyskinesia associated with subthalamic nucleus (STN) deep brain stimulation (DBS).
Ashok Sriram, Kelly D. Foote, Genko Oyama, Joshua Kwak, Pamela R. Zeilman, Michael S. Okun   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Regional reduction of high-energy phosphorus metabolites characterizes the cerebellar subtype of multiple system atrophy

npj Parkinson's Disease
Multiple system atrophy (MSA) is a severe neurodegenerative disorder with various underlying pathophysiological features. Mitochondrial dysfunction has been implied as a viable treatment target in patients with MSA.
Jannik Prasuhn, Christina Bodemann, Britt Ebeling, Katharina Reuther, Sinja S. Großer, Jan Uter, Julia Henkel, Henrike Hanssen, Norbert Brüggemann   +8 more
doaj   +1 more source

Movement disorders in genetically confirmed mitochondrial disease and the putative role of the cerebellum.

, 2018
BACKGROUND Mitochondrial disease can present as a movement disorder. Data on this entity's epidemiology, genetics, and underlying pathophysiology, however, is scarce.
Schaller, André, Galovic, Marian, Michels, Lars, Kägi, Georg, Hidding, Ute, Jung, Hans H, Waldvogel, Daniel, Schreglmann, Sebastian R, Ganos, Christos, Bhatia, Kailash, Krasemann, Ernst, Baumann, Christian R, Riederer, Franz, Jaunmuktane, Zane   +13 more
core   +1 more source

Cardiac Involvement in Movement Disorders

, 2021
Background: Several conditions represented mainly by movement disorders are associated with cardiac disease, which can be overlooked in clinical practice in the context of a prominent primary neurological disorder.
Wainsztein, Nestor, Wainsztein, Néstor Adrián, Merello, Marcelo, Nestor Wainsztein, Malco Rossi, Rossi, Malco, Marcelo Merello, Rossi, Malco Damian, Merello, Marcelo Jorge   +8 more
core   +1 more source