Results 91 to 100 of about 3,254,927 (309)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Sleepiness and Depression in Parkinson's Disease Patients Treated with Ropinirole and Levodopa [PDF]

, 2017
OBJECTIVE: We aimed to investigate the effect of ropinirole on excessive daytime sleepiness (EDS) and depression in Parkinson's disease (PD) with a large population.
손영호, 선우문경
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Movement difficulties in children [PDF]

, 2011
The development of adequate motor control and coordination is an important part of general development, allowing an infant to interact with and learn about the world around them and making possible so many everyday activities for children - at home, at ...
Barnett, Anna, Hill, Elisabeth L.
core   +4 more sources

Heterozygous variants in AP4S1 are not associated with a neurological phenotype

Annals of Clinical and Translational Neurology
Biallelic loss‐of‐function variants in AP4S1 cause childhood‐onset hereditary spastic paraplegia. A recent report suggested that heterozygous AP4S1 variants lead to a syndrome of lower limb spasticity and dysregulation of sphincter function.
Vicente Quiroz, Umar Zubair, Luca Schierbaum, Amy Tam, Nicole Battaglia, Joshua Rong, Habibah A. P. Agianda, Julian E. Alecu, Kathryn Yang, Darius Ebrahimi‐Fakhari   +9 more
doaj   +1 more source

Rapid eye movement sleep behavior disorder: modern concept and Parkinson’s disease correlation [PDF]

Анналы клинической и экспериментальной неврологии
This review describes the association between rapid eye movement (REM) sleep behavior disorder (RBD) and synucleinopathies, primarily Parkinson's disease.
Diana M. Khasanova, Zuleykha A. Zalyalova, Guzal R. Ilina, Nailya I. Bagdanova   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The gap between clinical gaze and systematic assessment of movement disorders after stroke [PDF]

, 2012
Background: Movement disorders after stroke are still captured by clinical gaze and translated to ordinal scores of low resolution. There is a clear need for objective quantification, with outcome measures related to pathophysiological background. Neural
Meskers, Carel G.M., Arendzen, J. Hans, Van der Krogt, H.J.M. (author), De Groot, J.H., Carel GM Meskers, Klomp, A. (author), De Groot, J.H. (author), Jurriaan H de Groot, Van Der Krogt, Hanneke J.M., Klomp, A., Meskers, C.G.M. (author), Groot, J.H. de, Klomp, Asbjorn, Arendzen, J.H., Meskers, C.G.M., J Arendzen, Krogt, H.J.M. van der, Arendzen, J.H. (author), Van der Krogt, H.J.M., De Groot, Jurriaan H., Hanneke JM van der Krogt, Asbjørn Klomp   +21 more
core   +2 more sources

Postoperative and Postpartum Onset of Chronic Parkinsonism: Four Case Reports

International Journal of Medical Students, 2014
Background: Certain environmental exposures have been linked to the development of parkinsonism. We report four cases in which the onset of chronic parkinsonism occurred immediately or soon after surgery or childbirth.
Manish Ramani B., Marcie Rabin L., Roger Kurlan   +2 more
doaj   +3 more sources

Identifying maximal beta power from directional subthalamic local field potentials in Parkinson’s disease

npj Parkinson's Disease
Accurate subthalamic beta activity could guide deep brain stimulation programming in Parkinson’s disease, but bipolar recordings complicate contact selection. In 39 patients, we validated three methods to estimate pseudo-monopolar beta power.
Jennifer K. Behnke, Robert L. Peach, Moritz Gerster, Richard M. Köhler, Jeroen G. V. Habets, Johannes L. Busch, Varvara Mathiopoulou, Jonathan Kaplan, Lucia K. Feldmann, Juliette Vivien, Chi Wang Ip, Gerd-Helge Schneider, Katharina Faust, Patricia Krause, Andrea A. Kühn   +14 more
doaj   +1 more source