Results 101 to 110 of about 3,254,927 (309)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The Genetic Landscape of Complex Childhood-Onset Hyperkinetic Movement Disorders [PDF]

, 1992
Dystonia; Hyperkinetic movement disorders; Infantile parkinsonisDistonía; Trastornos del movimiento hipercinético; Parkinsonismo infantilDistonia; Trastorns del moviment hipercinètic; Parkinsonisme infantilBackground and Objective The objective of this ...
Danti, Federica R., Macaya, Alfons, Gorman, Kathleen, Macaya Ruíz, Alfons, Perez-Duenas, Belen, Barwick, Katy, Işıksungur, Halide, Danti, Federica Rachele, Marce-Grau, Anna, Perez Dueñas, Belen, Ortigoza-Escobar, Juan D., Ortigoza Escobar, Juan Dario, Marcé Grau, Anna   +12 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Consensus statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society [PDF]

, 2017
BACKGROUND: Consensus criteria for classifying tremor disorders were published by the International Parkinson and Movement Disorder Society in 1998.
Louis, Elan D, Bain, P, Peter Bain, Raethjen, J, Deuschl, Guenther, Hallett, M, Rodger J. Elble, Mark Hallett, Tremor Task Force of the International Parkinson and Movement Disorder Society, Bain, Peter, Jan Raethjen, Bajaj, Nin, Testa, CM, Kailash P. Bhatia, Elan D. Louis, Elble, RJ, Raethjen, Jan, Stamelou, Maria, Nin Bajaj, Maria Stamelou, Louis, ED, Testa, Claudia M, Stamelou, M, Claudia M. Testa, Guenther Deuschl, Bhatia, KP, null null, Elble, Rodger J, Hallett, Mark, Bajaj, N, Bhatia, Kailash P, Deuschl, G   +31 more
core   +1 more source

Drug-induced movement disorders : nosology and treatment. [PDF]

editorial reviewedMovements disorders are frequently encountered in general practice and emergency departments and are in many cases of iatrogenic origin.
Depierreux, Frédérique, MARTEN, Laurie
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Long-Term Real-World Experience with Safinamide in Patients with Parkinson’s Disease

Brain Sciences
Introduction: Randomized clinical trials should be complemented with data from real-world studies. We report our long-term experience with safinamide in a movement disorders unit.
Anna Planas-Ballvé, Núria Caballol Pons, Alejandro Peral Quirós, Isabel Gómez Ruiz, Marta Balagué Marmaña, Alexander J. Velázquez Ballester, Dolors Lozano Moreno, Asunción Ávila Rivera   +7 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source