Results 121 to 130 of about 3,376,946 (257)

Movement disorders in metabolic diseases in adulthood

, 2012
Introduction Inborn errors of metabolism (IEMs) are a wide and variegate, mostly recessively inherited group of multi-systemic diseases that often involve the central nervous system (CNS).
Schneider S. A., Bhatia K. P., Carecchio M., Miryam Carecchio, Susanne A. Schneider, Kailash P. Bhatia   +5 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice [PDF]

Basic Science is crucial for the advancement of clinical care for Movement Disorders. Here, we provide brief updates on how basic science is important for understanding disease mechanisms, disease prevention, disease diagnosis, development of novel ...
Lin, C-H, Standaert, DG, Vila, Miquel, The MDS Basic Science Special Interest Group Steering Committee, Ferrario, Juan, Taiwo, Lolade, Takahashi, Ryosuke, Taiwo, L, Ferrario, Juan Esteban, Salama, M., Bezard, Erwan, Outeiro, TF, Salama, Mohamed, Salama, M, Lin, C., Mollenhauer, Brit, Svenningsson, Per, Kalia, LV, Taiwo, L., Outeiro, Tiago F., Ferrario, J, Bezard, E., Svenningsson, P., Lin, Chin‐Hsien, Standaert, D., Mollenhauer, B., Lin, Chin Hsien, Takahashi, R., Vila, M, Kalia, L., Takahashi, R, Vila, M., Standaert, David G., Outeiro, T., Bezard, E, Kalia, Lorraine V., Ferrario, J.   +36 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Pathophysiology of Basal Ganglia Disorders: neurophysiological investigations. Rehabilitation in Movement Disorders

, 2013
An increasing number of neurophysiological studies have provided important information on the pathophysiology of different types of movement disorders, including hypokinetic disorders such as Parkinson’s disease and hyperkinetic movement disorders such ...
Alfredo Berardelli, Antonio Suppa, BERARDELLI, Alfredo, SUPPA, ANTONIO, Berardelli A., Suppa A.   +5 more
core   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Expanding molecular and clinical spectrum of CPT1C‐associated hereditary spastic paraplegia (SPG73)—a case series

Annals of Clinical and Translational Neurology
Autosomal‐dominant variants in the CPT1C gene have been associated with hereditary spastic paraplegia type 73 (SPG73), which typically presents with slowly progressive lower limb weakness and spasticity and is therefore considered a pure form of ...
Alexandra K. Brooks, Vicente Quiroz, Luca Schierbaum, Amy Tam, Julian E. Alecu, Darius Ebrahimi‐Fakhari   +5 more
doaj   +1 more source

Movement Disorders Curricula

, 2017
This book offers a comprehensive approach to the wide range of movement disorders, an important specialty in the field of neurology, guiding readers from the phenomenology to diagnosis and management.
Ferreira, Joaquim, Martinez-Martin, Pablo, Chaudhuri, Kallol Ray, Falup-Pecurariu, Cristian   +3 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source