Results 91 to 100 of about 990,766 (345)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

DNA Methylation Suppression by Bhendi Yellow Vein Mosaic Virus

Epigenomes, 2018
Bhendi yellow vein mosaic virus (BYVMV) belongs to the monopartite begomovirus associated with the β satellite. As a single-stranded DNA (ssDNA) virus, it should be amenable to transcriptional and post-transcriptional gene silencing (TGS and PTGS ...
Kandhalu Sagadevan Dinesh Babu, Ashirbad Guria, Jeyalakshmi Karanthamalai, Nagesh Srikakulam, Kamlesh Kumari, Priyanka Sharma, Sam Aldrin Chandran, Anburaj Daniel Barnabas, Jebasingh Tennyson, Gopal Pandi   +9 more
doaj   +1 more source

Voltage sensing in ion channels: Mesoscale simulations of biological devices [PDF]

, 2012
Electrical signaling via voltage-gated ion channels depends upon the function of a voltage sensor (VS), identified with the S1-S4 domain in voltage-gated K+ channels.
A. Hodgkin, A. Hodgkin, Alexander Peyser, B. Hille, Wolfgang Nonner   +4 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses

Frontiers in Plant Science, 2014
Synaptotagmins are a large gene family in animals that have been extensively characterized due to their role as calcium sensors to regulate synaptic vesicle exocytosis and endocytosis in neurons, and dense core vesicle exocytosis for hormone secretion ...
Asako eUchiyama, Harumi eShimada-Beltran, Amit eLevy, Judy Y Zheng, Parth A Javia, Sondra Gale Lazarowitz   +5 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Super-resolving microscopy reveals the localizations and movement dynamics of stressosome proteins in Listeria monocytogenes [PDF]

, 2023
Buu Minh Tran, Dmitrii Linnik, Christiaan M. Punter, Wojciech M. Śmigiel, Luca Mantovanelli, Aditya Iyer, Conor O’Byrne, Tjakko Abee, Jörgen Johansson, Bert Poolman   +9 more
openalex   +1 more source

Unusual features of pomoviral RNA movement [PDF]

, 2013
This work is partially supported by the Scottish Government’s Rural and Environment Science and Analytical Services (RESAS) DivisionPotato mop-top pomovirus (PMTV) is one of a few viruses that can move systemically in plants in the absence of the capsid ...
Bragard, Claude, Cowan, Graham H, Crutzen, Francois, Lukhovitskaya, Nina I, Savenkov, Eugene I, Torrance, Lesley, Wright, Kathryn M   +6 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Recent progress in research on cell-to-cell movement of rice viruses

Frontiers in Microbiology, 2014
To adapt to plants as hosts, plant viruses have evolutionally needed the capacity to modify the host plasmodesmata (PD) that connect adjacent cells. Plant viruses have acquired one or more genes that encode movement proteins (MPs), which facilitate the ...
Akihiro eHiraguri, Osamu eNetsu, Nobumitsu eSasaki, Hiroshi eNyunoya, Takahide eSasaya   +4 more
doaj   +1 more source