Results 91 to 100 of about 981,887 (296)

The D-ring, Not the A-ring, Rotates in Synechococcus OS-B' Phytochrome [PDF]

, 2014
Phytochrome photoreceptors in plants and microorganisms switch photochromically between two states, controlling numerous important biological processes.
Borucki, Borucki, Cornilescu, Essen, Falk, Falk, Goddard, Hahn, Hahn, Hu, Hughes, Inomata, Inomata, Ishizuka, Lamparter, Li, Mailliet, Rockwell, Rockwell, Rohmer, Rohmer, Rohmer, Röben, Rüdiger, Schmidt, Song, Song, Song, Strauss, Takegoshi, Thurber, Ulijasz, Ulijasz, van Thor, Wagner, Wagner, Yang, Yang, Yang, Yang, Zhao   +40 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease

npj Parkinson's Disease, 2023
Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson’s disease (PD) associated mutations and found them to be ...
Sara Gomes, Alicia Garrido, Francesca Tonelli, Donina Obiang, Eduardo Tolosa, Maria José Martí, Javier Ruiz-Martínez, Ana Vinagre-Aragón, Haizea Hernandez-Eguiazu, Ioana Croitoru, Vicky L. Marshall, Theresa Koenig, Christoph Hotzy, Frank Hsieh, Marianna Sakalosh, Elizabeth Tengstrand, Shalini Padmanabhan, Kalpana Merchant, Christof Bruecke, Walter Pirker, Alexander Zimprich, Esther Sammler   +21 more
doaj   +1 more source

Spring Barley Seeding Rate and Interseeding Trial [PDF]

, 2015
With the revival of the small grains industry in the Northeast and the strength of the localvore movement, craft breweries and distilleries have expressed an interest in sourcing local barley for malting.
Calderwood, Lily, Cubins, Julija, Cummings, Erica, Darby, Heather, Gupta, Abha, Post, Julian, Ziegler, Sara   +6 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

DNA Methylation Suppression by Bhendi Yellow Vein Mosaic Virus

Epigenomes, 2018
Bhendi yellow vein mosaic virus (BYVMV) belongs to the monopartite begomovirus associated with the β satellite. As a single-stranded DNA (ssDNA) virus, it should be amenable to transcriptional and post-transcriptional gene silencing (TGS and PTGS ...
Kandhalu Sagadevan Dinesh Babu, Ashirbad Guria, Jeyalakshmi Karanthamalai, Nagesh Srikakulam, Kamlesh Kumari, Priyanka Sharma, Sam Aldrin Chandran, Anburaj Daniel Barnabas, Jebasingh Tennyson, Gopal Pandi   +9 more
doaj   +1 more source

Comprehensive short and long read sequencing analysis for the Gaucher and Parkinson’s disease-associated GBA gene

Communications Biology, 2022
GBA variants carriers are at increased risk of Parkinson’s disease (PD) and Lewy body dementia (LBD). The presence of pseudogene GBAP1 predisposes to structural variants, complicating genetic analysis.
Marco Toffoli, Xiao Chen, Fritz J. Sedlazeck, Chiao-Yin Lee, Stephen Mullin, Abigail Higgins, Sofia Koletsi, Monica Emili Garcia-Segura, Esther Sammler, Sonja W. Scholz, Anthony H. V. Schapira, Michael A. Eberle, Christos Proukakis   +12 more
doaj   +1 more source

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]

, 2019
During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna, Goh, Ryan, Kong, Xiangyu, Liu, Lizhong, Warmflash, Aryeh   +4 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses

Frontiers in Plant Science, 2014
Synaptotagmins are a large gene family in animals that have been extensively characterized due to their role as calcium sensors to regulate synaptic vesicle exocytosis and endocytosis in neurons, and dense core vesicle exocytosis for hormone secretion ...
Asako eUchiyama, Harumi eShimada-Beltran, Amit eLevy, Judy Y Zheng, Parth A Javia, Sondra Gale Lazarowitz   +5 more
doaj   +1 more source