Results 231 to 240 of about 9,249 (288)

Ivermectin and moxidectin against soil-transmitted helminth infections.

Trends in Parasitology, 2023
Ivermectin and moxidectin, two macrocyclic lactones, are potent antiparasitic drugs currently registered and mainly used against filarial diseases; however, their potential value for improved soil-transmitted helminth (STH) control has been acknowledged.
Eveline Hürlimann, D. Hofmann, J. Keiser   +2 more
semanticscholar   +4 more sources

Efficacy and safety of moxidectin-albendazole and ivermectin-albendazole combination therapy compared to albendazole monotherapy in adolescents and adults infected with Trichuris trichiura: a randomized controlled superiority trial.

Clinical Infectious Diseases, 2023
BACKGROUND The currently recommended benzimidazole monotherapy is insufficiently effective to control infection with the soil-transmitted helminth Trichuris trichiura. Ivermectin-albendazole combination has shown promising, but setting-dependent efficacy,
Viviane P. Sprecher, J. Coulibaly, Eveline Hürlimann, J. Hattendorf, J. Keiser   +4 more
semanticscholar   +1 more source

Efficacy of levamisole, ivermectin and moxidectin against Capillaria spp. in European hedgehogs (Erinaceus europaeus)

Journal of Helminthology, 2023
This randomised study aimed to assess and compare the efficacy of treatment protocols containing levamisole, ivermectin, or moxidectin against Capillaria spp.
Y. Van de Weyer, M.C. Santos, N. Williams, A. M. Gonçalves, W. Hawley, K. McVay, S. Bexton   +6 more
semanticscholar   +1 more source

Moxidectin induces autophagy arrest in colorectal cancer

Medical Oncology, 2022
Colorectal cancer (CRC) is a cancer with a high morbidity and mortality worldwide. Hence, developing new therapeutic drugs for CRC is very important. Moxidectin (MOX) has shown good anti-glioblastoma effect both in vitro and in vivo. This study aimed to elucidate the anti-CRC effect of MOX and its potential mechanism by investigating the influence of ...
Yushan Mao, Hanhan Xie, Dan Shu, Lin Cheng, Jingbin Lan, Kejian Pan   +5 more
openaire   +2 more sources

Presumed moxidectin toxicosis in three foals

Journal of the American Veterinary Medical Association, 1999
Outcome and complications associated with administration of moxidectin gel to 3 foals < 4 months old are described. Two foals became comatose but survived following supportive treatment. One foal died following loss of consciousness associated with moxidectin administration. Risk of moxidectin overdose exists, because horse owners often fail to read or
P J, Johnson, D R, Mrad, A J, Schwartz, L, Kellam   +3 more
openaire   +2 more sources

Moxidectin unravels the role of Hippo-YAP pathway in maintaining immunity of glioblastoma multiforme.

Molecular Cancer Therapeutics
Glioblastoma multiforme (GBM) is a lethal and aggressive cancer with an extremely poor prognosis. Recent preclinical, clinical and genomic studies have highlighted the role of Hippo-Yap pathway in the progression of GBM.
Itishree Kaushik, Robin Rajan, S. Gaikwad, M. Eltokhy, S. Srivastava   +4 more
semanticscholar   +1 more source

Analytical Profile of Moxidectin

2013
Moxidectin or F28249α is a potent endectocide and semisynthetic methoxime derivative of naturally occurring nemadectin. It is well known for the novel mode of action against a broad range of nematode and anthropod animal parasites. In this work, physicochemical and pharmaceutical aspects of moxidectin are described including stability, semisynthesis ...
Atul, Awasthi, Majid, Razzak, Raida, Al-Kassas, Joanne, Harvey, Sanjay, Garg   +4 more
openaire   +3 more sources

Moxidectin: Absorption, Tissue Distribution, Excretion, and Biotransformation of 14C-Labeled Moxidectin in Sheep

Journal of Agricultural and Food Chemistry, 1994
The absorption, tissue distribution, excretion, and biotransformation of moxidectin, a novel endectocide that combats internal and external parasites in sheep, cattle, and horse, were studied in sheep. Following a single oral administration of a 1:1 mixture of 14 C- and deuterium-labeled moxidectin at 0.2 mg/g of body weight, the highest residue ...
Jalees Afzal, Steven J. Stout, Adrian R. daCunha, Phillip Miller   +3 more
openaire   +1 more source

Parascaris equorum resistance to moxidectin?

Veterinary Record, 2008
SIR, — With reference to the letter from Martin Peaty ( VR , March 22, 2008, vol 162, p 387), suggesting that moxidectin resistance may now be present in Parascaris equorum in the uk, there are a few points that need to be considered.
openaire   +4 more sources