Epigenetic Rewiring and Context-Dependent Therapeutic Vulnerabilities in Myeloproliferative Neoplasms. [PDF]
Abdelgawwad El-Sehrawy AAM +7 more
europepmc +1 more source
Clinical management of clonal hematopoiesis
ABSTRACT Clonal hematopoiesis, particularly clonal hematopoiesis of indeterminate potential and clonal cytopenia of undetermined significance, is an age‐related premalignant condition characterized by the expansion of hematopoietic clones carrying somatic mutations.
Kelly S. Chien +1 more
wiley +1 more source
The Current Landscape of Pulmonary Hypertension in Myeloproliferative Neoplasms. [PDF]
Ferrante M, Ali HJ, Hobbs G, Leiva O.
europepmc +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Isolated del(5q) with myeloproliferative driver mutations: A systematic review of published cases and clinical implications. [PDF]
Abdulgayoom M +7 more
europepmc +1 more source
High Charge Carrier Mobility in Non‐Conjugated 3D Covalent Organic Frameworks
A non‐conjugated 3D COF constructed via boronate ester linkages from tetraphenylene and pyrene‐based monomers is reported, which exhibits a high charge carrier mobility of 14 ± 1 cm2 V−1 s−1. ABSTRACT π‐Conjugation, π–π stacking, and long‐range order play a central role in determining charge transport efficiency in organic materials.
Joaquín Almarza +11 more
wiley +1 more source
Enhancing Tumor Perfusion and Nanomedicine Delivery by Modulating Vascular Tone with Methyl Palmitate Nanoparticles. [PDF]
Palomba R +9 more
europepmc +1 more source
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen +13 more
wiley +1 more source
Inflammatory and Immune Microenvironment in Myeloproliferative Neoplasms: Pathogenic Mechanisms and Therapeutic Opportunities. [PDF]
Kaikavoosnejad F +9 more
europepmc +1 more source

