Results 181 to 190 of about 36,802 (283)

Collagen Turnover Is Associated with Disease Severity, Bone Marrow Fibrosis, and the <i>JAK2V617F</i> Variant Allele Frequency in Myeloproliferative Neoplasms. [PDF]

Cancers (Basel)
Bistrup CN, Larsen MK, Junker P, Skov V, Kjær L, Knudsen TA, Karsdal M, Willumsen N, Hasselbalch HC.   +8 more
europepmc   +1 more source

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Resistance to venetoclax has become a critical bottleneck limiting its long‐term clinical benefits. A thorough understanding of the underlying resistance mechanisms and the development of novel strategies to overcome resistance are central to improving survival outcomes in elderly AML patients. Abstract To date, the treatment of acute myeloid leukaemia
Jinlin Zhang, Jile Liu, Mohan Zhao, Xiaoyu Zhang, Linlin Liu, Mengnan Li, Changze Cao, Rui Zhang, Mingfeng Zhao   +8 more
wiley   +1 more source

Comprehensive High-Sensitivity Mutation Profiling in MPNs: Diagnostic and Prognostic Implications. [PDF]

Cancers (Basel)
Kim N, Kang Y, Kook HW, Chung H, Jang JE, Lee ST, Song J, Kim JS, Choi JR, Cheong JW, Shin S.   +10 more
europepmc   +1 more source

Single-cell long-read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML. [PDF]

Blood Adv
Grabek J, Straube J, Cooper L, Haldar R, Zhang R, Dulige I, Barker M, Gatehouse W, Christensen H, Amor G, Ling VY, McNamara C, Ross DM, Perkins A, Bywater MJ, Lane SW.   +15 more
europepmc   +1 more source

CPX-351 in combination with ruxolitinib for advanced-phase myeloproliferative neoplasms: results of a phase 1 study. [PDF]

Blood Neoplasia
Handa S, Madanat Y, Pugh K, Dvorak-Kornaus K, Zhao Q, Mims A, Koenig K, Srisuwananukorn A, Cook R, Swords R, Borate U.   +10 more
europepmc   +1 more source

The Germline SH2B3rs111340708 Splicing Variant Drives Intron Retention and Protein Instability by Impacting Clinical Outcomes in Core Binding Factor AML

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT The SH2B3 gene, also known as LNK, encodes an adaptor protein that negatively regulates key hematopoietic signaling pathways, including JAK–STAT, MAPK, and PI3K/AKT, thereby maintaining hematopoietic homeostasis. SH2B3 interacts with major signaling regulators such as JAK2, MPL, FLT3, and KIT. Loss‐of‐function alterations have been reported in
Marta Rachele Stefanucci, Livia Leuzzi, Linda Montavoci, Davide Paolo Bernasconi, Luca Cimaschi, Alessandra Trojani, Anna Caretti, Lorenzo Del Castello, Roberto Cairoli, Alessandro Beghini   +9 more
wiley   +1 more source

Nutrient starvation and phosphonate utilization coordinate buoyancy and high-light tolerance in Trichodesmium. [PDF]

Nat Commun
Zou C, Gao G, Lin X, Bizic M, Berman-Frank I, Gao K.   +5 more
europepmc   +1 more source

Salmonella enterica serovars co‐exist sporadically and at low abundance in US mid‐Atlantic irrigation ponds

Journal of the Science of Food and Agriculture, Volume 106, Issue 12, Page 7015-7022, September 2026.
Abstract BACKGROUND Spring or rain‐fed ponds are frequent features on US mid‐Atlantic farms. The need to conduct preharvest agricultural water assessments to identify microbial hazards, as required by the US Produce Safety Rule, highlights knowledge gaps pertaining to pond water adequacy for vegetable production.
Shirley A Micallef, Mary Theresa Callahan, Nikki W Shariat, Yisrael Katz, Xingchen Liu   +4 more
wiley   +1 more source

Inhibitory HLA-C/KIR2DL2 Interactions and KIR Allelic Polymorphisms Are Associated With Susceptibility to Philadelphia Chromosome-Negative Myeloproliferative Neoplasms. [PDF]

EJHaem
Shivarov V, Tsvetkova G, Hadjiev E, Ivanova M.   +3 more
europepmc   +1 more source

Risk of Myeloproliferative Neoplasms in Patients With Inflammatory Bowel Disease and Impact on Outcomes: A Multi-Centre Matched Analysis. [PDF]

Aliment Pharmacol Ther
Eldesouki MH, Ibrahim A, Marey MM, Francis FF, Alsakarneh S, Ayala E, Shaukat A, Farraye FA, Hashash JG.   +8 more
europepmc   +1 more source