Results 101 to 110 of about 101,642 (212)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

3D Large‐Scale Subwavelength‐Resolution Sound Sheet Tomography Based on an Active and Programmable Circular Meta‐Array

Advanced Science, EarlyView.
A programmable 2048‐element circular ultrasound array combined with a compact acoustic lens produces a thin “sound sheet” over a large field of view, and records echoes with wide angular diversity across the ring aperture. Coherence‐enhanced beamforming converts full‐matrix data into high‐contrast tomographic slices, delivering near‐diffraction‐limited
Qiu‐De Zhang, Zi‐Bin Lin, Zhuo Chen, Zhao‐Hui Liu, Jin‐Lian He, Jun‐Jie Song, Long‐Sheng Zeng, Liang Zhou, Ming‐Yue Ding, Yu‐Gui Peng, Ming Yuchi, Xue‐Feng Zhu   +11 more
wiley   +1 more source

Rapid Formation of Methemoglobin via Nitric Oxide Delivery for Potential Use as an MRI Contrast Agent. [PDF]

Ann Biomed Eng, 2023
Markwalter DJ, Primavera KD, Day RW, Lewis RS.   +3 more
europepmc   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent. [PDF]

Nat Commun, 2022
Dong L, Xu YJ, Sui C, Zhao Y, Mao LB, Gebauer D, Rosenberg R, Avaro J, Wu YD, Gao HL, Pan Z, Wen HQ, Yan X, Li F, Lu Y, Cölfen H, Yu SH.   +16 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Preparation and evaluation of LA-PEG-SPION, a targeted MRI contrast agent for liver cancer. [PDF]

Open Life Sci, 2022
Xia L, Song X, Yan G, Quan J, Jin G.
europepmc   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Simultaneous Evaluations of pH and Enzyme Activity with a CEST MRI Contrast Agent. [PDF]

ACS Sens, 2021
Kombala CJ, Lokugama SD, Kotrotsou A, Li T, Pollard AC, Pagel MD.   +5 more
europepmc   +1 more source

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source