Results 111 to 120 of about 101,642 (212)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Fabrication of Fe(III)-doped mesoporous silica nanoparticles as biocompatible and biodegradable theranostic system for Remdesivir delivery and MRI contrast agent. [PDF]

Inorg Chem Commun, 2023
Arkaban H, Jaberi J, Bahramifar A, Zolfaghari Emameh R, Farnoosh G, Arkaban M, Taheri RA.   +6 more
europepmc   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Development of a glutamine-responsive MRI contrast agent. [PDF]

Chem Sci
Wilson CA, Bruchs AT, Fatima S, Boggs DG, Bridwell-Rabb J, Olshansky L.   +5 more
europepmc   +1 more source

Effects of PEG Chain Length on Relaxometric Properties of Iron Oxide Nanoparticles-Based MRI Contrast Agent. [PDF]

Nanomaterials (Basel), 2022
Ge J, Li C, Wang N, Zhang R, Afshari MJ, Chen C, Kou D, Zhou D, Wen L, Zeng J, Gao M.   +10 more
europepmc   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Human Transthyretin with a Tailored Gd(III) Complex as a High-Relaxivity MRI Contrast Agent. [PDF]

Inorg Chem
Bindi J, Kubrak A, Lei Y, Kaster M, Cerofolini L, Ravera E, Meade TJ, Fragai M, Parigi G.   +8 more
europepmc   +1 more source

Effect of Europium Substitution on the Structural, Magnetic and Relaxivity Properties of Mn-Zn Ferrite Nanoparticles: A Dual-Mode MRI Contrast-Agent Candidate. [PDF]

Nanomaterials (Basel), 2023
Saeidi H, Mozaffari M, Ilbey S, Dutz S, Zahn D, Azimi G, Bock M.   +6 more
europepmc   +1 more source

Magnetoelectric Nanoparticle‐Based Wireless Brain–Computer Interface: Underlying Physics and Projected Technology Pathway

Advanced Science, EarlyView.
Magnetoelectric nanoparticles (MENPs) enable fully wireless, minutely invasive neuromodulation, and potentially neural recording, by converting magnetic into electric and, conversely, electric into magnetic fields, respectively, at high spatiotemporal resolution.
Elric Zhang, Max Shotbolt, Mostafa Abdel‐Mottaleb, Shawnus Chen, Victoria Andre, Jieyuan Tian, Jonathan Shulgach, Max Murphy, Brian Noga, Ping Liang, Darcy Griffin, Douglas Weber, Marta Pardo, Salvador Pane, Sakhrat Khizroev   +14 more
wiley   +1 more source

Effect of sampling volume on measurements of size and chemical homogeneity of MRI contrast agent FeraSpin™ R. [PDF]

Nanoscale Adv
Maceratesi V, Doveri LR, Engel N, Cantoni E, Pallavicini P, Milanese C, Sack F, Gehrke N, Briel A, Lambeng N, Douri S, Chivas-Joly C, Alasonati E, de Carsalade du Pont V, Sapalidis D, Gerina M, Silva BFB, Tache O, Lee WA, Cant DJH, Minelli C, Gollwitzer C, Schürmann R, Diaz Fernandez YA.   +23 more
europepmc   +1 more source