Results 11 to 20 of about 19,153 (149)

Renal Lesions in MRL Mice [PDF]

Veterinary Pathology, 1982
Female MRL-Mp- lpr/ lpr mice spontaneously develop autoimmune disease at three to five months of age and die most commonly from immune complex glomerulonephritis. Kidneys of two-month-old females appeared nearly normal by electron microscopy, and glomerular deposits of IgG and complement component 3 (C3) barely were detectable.
G J, Kolaja, P E, Fast
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Antibody enhanced HPLC for serotype-specific quantitation of polysaccharides in pneumococcal conjugate vaccine

npj Vaccines, 2023
Bacterial infection remains as one of the major healthcare issues, despite significant scientific and medical progress in this field. Infection by Streptococcus Pneumoniae (S. Pneumoniae) can cause pneumonia and other serious infectious diseases, such as
James Z. Deng, Nathan Kuster, Ashley Drumheller, Mingxiang Lin, Frances Ansbro, Milica Grozdanovic, Rachelle Samuel, Ping Zhuang   +7 more
doaj   +1 more source

Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between Hot-Melt Extrusion and Spray Drying

Pharmaceutics, 2021
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility.
Yongjun Li, Amanda K. P. Mann, Dan Zhang, Zhen Yang   +3 more
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SPATA2 and CYLD inhibit T cell infiltration into colorectal cancer via regulation of IFN-γ/STAT1 axis

Frontiers in Oncology, 2022
IntroductionColorectal cancer (CRC) is largely refractory to currently available immunotherapies such as blockade of programmed cell death protein-1 (PD-1).ResultsIn this study, we identified SPATA2 and its protein partner CYLD as novel regulators of CXC-
Tze Guan Tan, Yulia Zybina, Cooper McKenna, Aleksandra Olow, Subhadra Jayaraman Rukmini, Michael Thomas Wong, Svetlana Sadekova, Alissa Chackerian, David Bauché   +8 more
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Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology

Neurobiology of Disease, 2021
TDP-43 pathology is a hallmark of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal lobar degeneration (FTLD). Namely, both diseases feature aggregated and phosphorylated TDP-43 containing inclusions in the cytoplasm and a loss of nuclear TDP-43 in ...
Yuan Tian, Yi Wang, Angela M. Jablonski, Yinghui Hu, Jonathan A. Sugam, Markus Koglin, Shawn J. Stachel, Heather Zhou, Jason M. Uslaner, Sophie Parmentier-Batteur   +9 more
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Evaluation of Pesticide Residues in Vegetables from the Asir Region, Saudi Arabia

Molecules, 2020
This study’s aim was to determine the pesticide residues in 10 different vegetable commodities from the Asir region, Saudi Arabia. We evaluated 211 vegetable samples, collected from supermarkets between March 2018 and September 2018, for a total of
Mohamed F. A. Ramadan, Mohamed M. A. Abdel-Hamid, Montasser M. F. Altorgoman, Hamed A. AlGaramah, Mohammed A. Alawi, Ali A. Shati, Hoda A. Shweeta, Nasser S. Awwad   +7 more
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A novel approach to determine residual aldehyde content in conjugated polysaccharides with 3-methyl-2-benzothiazolinonehydrazon (MBTH) by colorimetric method, automation, and HP-SEC

Journal of Pharmaceutical and Biomedical Analysis Open, 2023
Polysaccharide activation by periodate oxidation to form aldehydes, followed by conjugation with proteins via reductive amination is a general procedure to make polysaccharide-protein conjugate vaccines.
Weidong Tong, Mingxiang Lin, Ping Zhuang, Bukuru Anaclet, Castle Cooper   +4 more
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MRL-based Importance Measures [PDF]

Proceedings of the 29th European Safety and Reliability Conference (ESREL), 2019
In this paper, we propose a novel importance measure, namely LIM, which is defined as the improvement ability in the system residual life when replacing a component/group of components at a given time. LIM measure allows considering the current condition (state or degradation level) of all components at given time and the system structure into a single
Phuc Do, Christophe Berenguer, Emanuele Borgonovo   +2 more
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Functionally inactivated dominant viral antigens of human cytomegalovirus delivered in replication incompetent adenovirus type 6 vectors as vaccine candidates

Human Vaccines & Immunotherapeutics, 2017
T cell immunity is critical in controlling human cytomegalovirus (HCMV) infection in transplant recipients, and T cells targeting viral immediate early proteins such as IE1, IE2 and pp65 have been speculated to be more effective against reactivation ...
Aimin Tang, Daniel C. Freed, Fengsheng Li, Steve Meschino, Michael Prokop, Andrew Bett, Danilo Casimiro, Dai Wang, Tong-Ming Fu   +8 more
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Antibody-drug conjugates: integrated bioanalytical and biodisposition assessments in lead optimization and selection

AAPS Open, 2018
Therapies based on monoclonal antibodies (mAbs) have delivered an impressive success in the clinics due to their exquisite specificity, potential for agonistic or antagonistic responses, tunable effector function, and optimal pharmacokinetic properties ...
Maribel Beaumont, Daniela Tomazela, Douglas Hodges, Grigori Ermakov, Edward Hsieh, Isabel Figueroa, On-Yee So, Yaoli Song, Huiping Ma, Svetlana Antonenko, Wondwessen Mengesha, Yi Wei Zhang, Shuli Zhang, SuChun Hseih, Gulesi Ayanoglu, Xiaoyan Du, Eric Rimmer, Michael Judo, Franklin Vives, Jennifer H. Yearley, Christina Moon, Anthony Manibusan, Nick Knudsen, Andy Beck, Damien Bresson, Dennis Gately, Divas Neupane, Enrique Escandón   +27 more
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