Results 11 to 20 of about 81,219 (271)

Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases

Communications Biology, 2023
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA viruses responsible for severe respiratory infections and resulting disease in infants, elderly, and immunocompromised adults1–3.
Victoria A. Kleiner, Thierry O. Fischmann, John A. Howe, Douglas C. Beshore, Michael J. Eddins, Yan Hou, Todd Mayhood, Daniel Klein, Debbie D. Nahas, Bob J. Lucas, He Xi, Edward Murray, Daphne Y. Ma, Krista Getty, Rachel Fearns   +14 more
doaj   +1 more source

Single cell multi-omic reference atlases of non-human primate immune tissues reveals CD102 as a biomarker for long-lived plasma cells

Communications Biology, 2022
CD102 is an enriched biomarker for long-lived plasma cells in non-human primates (NHPs) and is conserved across NHPs, humans, and mice.
Ryan P. Staupe, Kenneth E. Lodge, Nithya Thambi, David Toole, Alex M. Tamburino, Dan Chang, Bonnie J. Howell, Daria J. Hazuda, Kalpit A. Vora, Nicole L. Sullivan   +9 more
doaj   +1 more source

Antibody enhanced HPLC for serotype-specific quantitation of polysaccharides in pneumococcal conjugate vaccine

npj Vaccines, 2023
Bacterial infection remains as one of the major healthcare issues, despite significant scientific and medical progress in this field. Infection by Streptococcus Pneumoniae (S. Pneumoniae) can cause pneumonia and other serious infectious diseases, such as
James Z. Deng, Nathan Kuster, Ashley Drumheller, Mingxiang Lin, Frances Ansbro, Milica Grozdanovic, Rachelle Samuel, Ping Zhuang   +7 more
doaj   +1 more source

Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between Hot-Melt Extrusion and Spray Drying

Pharmaceutics, 2021
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility.
Yongjun Li, Amanda K. P. Mann, Dan Zhang, Zhen Yang   +3 more
doaj   +1 more source

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]

, 1996
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Feng, G.J., Huang, F.P., Liew, F.Y., Lindop, G., Stott, D.I.   +4 more
core   +3 more sources

SPATA2 and CYLD inhibit T cell infiltration into colorectal cancer via regulation of IFN-γ/STAT1 axis

Frontiers in Oncology, 2022
IntroductionColorectal cancer (CRC) is largely refractory to currently available immunotherapies such as blockade of programmed cell death protein-1 (PD-1).ResultsIn this study, we identified SPATA2 and its protein partner CYLD as novel regulators of CXC-
Tze Guan Tan, Yulia Zybina, Cooper McKenna, Aleksandra Olow, Subhadra Jayaraman Rukmini, Michael Thomas Wong, Svetlana Sadekova, Alissa Chackerian, David Bauché   +8 more
doaj   +1 more source

A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration. [PDF]

, 2015
The leading edge of migrating cells contains rapidly translocating activated integrins associated with growing actin filaments that form 'sticky fingers' to sense extracellular matrix and guide cell migration.
Ablack, Jailal N, Bachir, Alexia I, Ginsberg, Mark H, Horwitz, Alan F, Lagarrigue, Frederic, Lee, Ho-Sup, Vikas Anekal, Praju   +6 more
core   +2 more sources

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome [PDF]

, 2019
Purpose: Sjögren syndrome is an autoimmune disorder that occurs almost exclusively in women and is associated with extensive inflammation in lacrimal tissue, an immune-mediated destruction and/or dysfunction of glandular epithelial cells, and a ...
Kam, Wendy R., Lieberman, Scott M., Morthen, Mathias Kaurstad, Rahimi Darabad, Raheleh, Richards, Stephen M., Sullivan, David A., Tellefsen, Sara   +6 more
core   +2 more sources

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus [PDF]

, 2015
Introduction ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE).
Harnett, M. M., Harnett, W., Pineda, M. A., Rodgers, D. T., Suckling, C. J.   +4 more
core   +1 more source

B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus [PDF]

, 2016
Background: Neuropsychiatric lupus (NPSLE) can be one of the earliest clinical manifestations in human lupus. However, its mechanisms are not fully understood.
A Ahuja, A Altman, A Fanouriakis, A Ivanova, A Katzav, A Unterman, A Zameer, A Zameer, AD Stock, AE Gharavi, AM Khalil, Ariel Stock, B Sakic, B Sakic, B Sakic, C Choi, C Gemma, C Kowal, C Kowal, Chaim Putterman, D Perry, DA Ballok, DA Ballok, DG Alleva, DK Dunn-Walters, G Steup-Beekman, GK Bertsias, H Fragoso-Loyo, H Fragoso-Loyo, H Okamoto, H Suzuki, Haowei Wang, HX Gao, I Marin, J Wen, J Wen, Jessica Doerner, JF Cryan, JG Hanly, Jing Wen, JJ Alexander, JJ Alexander, LL Teichmann, M Bravo-Zehnder, M Gulinello, M Gulinello, M Hughes, M Stanojcic, M Tokunaga, Maria Gullinello, Mark J. Shlomchik, MD Bauman, NC Derecki, NJ Abbott, O Chan, OT Chan, PD Cole, RN Hiramoto, S Kivity, S Mandlekar, S Najjar, S Sciascia, Samantha Chalmers, SL Eko, T Cobo-Ibanez, T Gono, Y Arinuma, Y Li, Y Li, Y Sherer, Y Ziv   +70 more
core   +3 more sources