Disease Site‐Specific Outcomes in p16‐Positive Non‐Oropharyngeal Mucosal Head and Neck Cancer
ABSTRACT Objectives To report disease‐free survival (DFS) in p16‐positive non‐oropharyngeal head‐and‐neck squamous‐cell carcinoma (HNSCC). Methods Curatively‐treated non‐oropharyngeal HNSCC (2009–2021) were reviewed. DFS was compared among p16‐positive, p16‐negative, and p16‐untested cases for the overall cohort and by disease site.
Revadhi C. Chelvarajah +21 more
wiley +1 more source
Reasoned opinion on the modification of the existing MRL for pyridate in celery leaves (dill leaves)
<p>In accordance with Article 6 of Regulation (EC) No 396/2005, Germany, hereafter referred to as the evaluating Member State (EMS), received an application from the State Institute for Agriculture, Forestry and Horticulture Saxony-Anhalt to modify
European Food Safety Authority
core +1 more source
Early‐life exposures may influence immune system development and, in turn, affect cancer susceptibility. In this population‐based case‐control study, the authors examined whether in utero or early childhood exposures were associated with the risk of developing multiple myeloma in adulthood.
Zhuoyu Sun +10 more
wiley +1 more source
Reasoned opinion on the modification of the existing MRL for 8-hydroxyquinoline in tomatoes
In accordance with Article 6 of Regulation (EC) No 396/2005, Spain, hereafter referred to as the evaluating Member State (EMS), received an application from the company Probelte to modify the existing MRL for the active substance 8-hydroxyquinoline in ...
European Food Safety Authority
core +1 more source
The applicants Bayer SAS – Crop Science Division, Diachem S.p.A. and Isagro S.p.A., submitted two requests to the competent national authority in Austria to evaluate the confirmatory data identified for deltamethrin in the framework of the maximum ...
Renata Leuschner +20 more
core +1 more source
Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival
ABSTRACT Breast cancer remains a major challenge to public health. Biomarkers may be useful to improve prediction of breast cancer survival. Several epigenetic markers of cell division and ageing based on DNA methylation have been proposed. In this study, we measured these epigenetic markers in breast tumours and assessed their prognostic value.
Luca Li +10 more
wiley +1 more source
Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Anders, Hans-Joachim +3 more
core +1 more source
Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang +7 more
wiley +1 more source
Half a Century of Per‐ and Polyfluoroalkyl Substances in Northern Gannet Eggs: Impact of Regulations
ABSTRACT Per‐ and polyfluoroalkyl substances (PFAS), known as “forever chemicals”, are persistent organic pollutants that have been widely used in the industry across the globe for many decades. Their chemical stability, bioaccumulation, and toxicity pose major environmental and health risks. This study examines temporal trends in the concentrations of
Anaïs Fournier +2 more
wiley +1 more source
Reasoned opinion on the modification of the existing MRLs for pyriproxyfen in stone fruits and tea
In accordance with Article 6 of Regulation (EC) No 396/2005, the Netherlands, hereafter referred to as the evaluating Member State (EMS), received an application from Sumitomo Chemical Agro Europe S.A.S. to set import tolerances for pyriproxyfen in stone
European Food Safety Authority
doaj +1 more source

