Results 121 to 130 of about 4,415 (202)

From Concept to Clinic: Pre‐Clinical Testing and Regulatory Considerations in Spine Implant Development

JOR SPINE, Volume 9, Issue 2, June 2026.
Spine implant development follows a regulated, iterative pathway from clinical need and design through material selection, prototyping, preclinical validation, and regulatory approval to post‐market surveillance. Biomechanical evaluation and risk‐based frameworks integrate across all stages, ensuring safe, effective translation from concept to clinical
Amit Benady, Jerrin Thadathil Varghese, Ryan David Quarrington, Morsi Khashan, B. Gangadhara Prusty, Ashish Diwan   +5 more
wiley   +1 more source

Setting of new MRLs for amisulbrom in wine and table grapes [PDF]

EFSA Journal, 2009
openaire   +1 more source

Prognostic Value of Impaired Vocal Cord Mobility in T2N0 Glottic Cancer Treated With IMRT

The Laryngoscope, Volume 136, Issue 6, Page 2605-2613, June 2026.
T2N0M0 glottic cancers with impaired vocal cord mobility (VCM) have worse outcomes than T2N0M0 tumors with normal VCM, but still fare better than T3N0M0 disease. These findings support subdivision of T2 glottic cancer into T2a (normal VCM) and T2b (impaired VCM) in future TNM revisions.
Alexander Rühle, Ranjan Subramani, Jie Su, Brian O'Sullivan, John N. Waldron, Andrew Hope, Andrew Bayley, Andrew McPartlin, Nauman Malik, Scott V. Bratman, Ali Hosni, John Kim, Ian Witterick, John R. de Almeida, Christopher Yao, Anna Spreafico, C. Jillian Tsai, Li Tong, Wei Xu, Shao Hui Huang, Ezra Hahn   +20 more
wiley   +1 more source

Stearoyl‐CoA Desaturase‐1 Drives Tumor Growth by Interacting With Histone Deacetylase‐2 and Deacetylating Nucleophosmin‐1

MedComm, Volume 7, Issue 6, June 2026.
Hypoxia induces SCD1 and PLIN2 to drive lipid droplet‐dependent metabolic adaptation in cancer cells. PLIN2 supports survival under stress, whereas SCD1 promotes proliferation upon reoxygenation and remodels the acetylome via HDAC2‐mediated NPM1 deacetylation and destabilization.
Coline Wery, Laetitia Montero‐Ruiz, Eric Bonneil, Mohammad Farran, Robin Jehay, Quentin Herrara Garfia, Gregory Fettweis, Silvia Blacher, Charles Pottier, Gael Cobraiville, Yasmine Boumahd, Olivier Peulen, Agnès Noël, Franck Dequiedt, Marianne Fillet, Nor Eddine Sounni   +15 more
wiley   +1 more source

Cluster Trials Inference With CARE

Statistics in Medicine, Volume 45, Issue 13-14, June 2026.
ABSTRACT We show that cluster‐randomized trials—especially pragmatic designs—often exhibit substantial (but underappreciated in practice) heterogeneity in cluster sizes and structures, distorting inference. Our simulations—reassigning treatment in real data and varying imbalance in synthetic data—show that currently recommended methods (such as ...
Sergey Alexeev, Rachael L. Morton
wiley   +1 more source

Lack of confirmatory data following Article 12 MRL reviews for dicloran, fenazaquin and tebufenozide. [PDF]

EFSA J
European Food Safety Authority (EFSA).
europepmc   +1 more source

Feasibility of Crosshole Seismic Tomography for Monitoring In Situ CO2 Mineral Storage in Basalts: A Rock Physics‐ and Seismic Modeling Study

Geochemistry, Geophysics, Geosystems, Volume 27, Issue 6, June 2026.
Abstract In situ CO2 mineral storage is gaining increasing attention as a carbon capture and storage (CCS) technology to reduce anthropogenic CO2 emissions. So far, in situ CO2 mineral storage projects have been monitored predominantly using fluid‐ and isotope geochemical methods.
Jonas Simon Junker, Hansruedi Maurer, Alba Zappone, Sin‐Mei Wu, Anne Obermann   +4 more
wiley   +1 more source

Assessment of fall-back MRLs for revoked CXLs previously implemented in the EU legislation. [PDF]

EFSA J
European Food Safety Authority (EFSA).
europepmc   +1 more source

Comparative Dynamics of Substorms and Sawtooth Events

Journal of Geophysical Research: Space Physics, Volume 131, Issue 6, June 2026.
Abstract We present a comprehensive comparative analysis of magnetospheric substorms and sawtooth events using multi‐point observations from ground‐based magnetometers, geostationary satellites, and the Time History of Events and Macroscale Interactions during Substorms mission.
C. C. DiMarco, T. I. Pulkkinen, R. L. McPherron, M. G. Henderson, J. W. Gjerloev   +4 more
wiley   +1 more source

Evaluation of confirmatory data following the Article 12 MRL review for isoxaben. [PDF]

EFSA J
European Food Safety Authority (EFSA), Bellisai G, Bernasconi G, Carrasco Cabrera L, Castellan I, Del Aguila M, Ferreira L, Greco L, Leuschner R, Mioč A, Nave S, Reich H, Ruocco S, Scarlato AP, Szot M, Theobald A, Tiramani M, Verani A, Zioga E.   +18 more
europepmc   +1 more source