Results 121 to 130 of about 6,871 (234)

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

open access: yesiNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong   +5 more
wiley   +1 more source

Agency for Toxic Substances and Disease Registry minimal risk levels (MRLs) [PDF]

open access: yes
The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) [42 U.S.C. 9604 et seq.], as amended by the Superfund Amendments and Reauthorization Act (SARA) [Pub. L. 99 499], requires that the Agency for Toxic Substances and Disease

core  

From Concept to Clinic: Pre‐Clinical Testing and Regulatory Considerations in Spine Implant Development

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
Spine implant development follows a regulated, iterative pathway from clinical need and design through material selection, prototyping, preclinical validation, and regulatory approval to post‐market surveillance. Biomechanical evaluation and risk‐based frameworks integrate across all stages, ensuring safe, effective translation from concept to clinical
Amit Benady   +5 more
wiley   +1 more source

Prognostic Value of Impaired Vocal Cord Mobility in T2N0 Glottic Cancer Treated With IMRT

open access: yesThe Laryngoscope, Volume 136, Issue 6, Page 2605-2613, June 2026.
T2N0M0 glottic cancers with impaired vocal cord mobility (VCM) have worse outcomes than T2N0M0 tumors with normal VCM, but still fare better than T3N0M0 disease. These findings support subdivision of T2 glottic cancer into T2a (normal VCM) and T2b (impaired VCM) in future TNM revisions.
Alexander Rühle   +20 more
wiley   +1 more source

Reasoned opinion on the modification of the existing MRLs for tebufenpyrad in cucumbers and courgettes

open access: yes, 2012
In accordance with Article 6 of Regulation (EC) No 396/2005, Germany, herewith referred to as the evaluating Member State (EMS), compiled an application to modify the existing MRLs for tebufenpyrad in cucumbers and courgettes. In order to accommodate for
European Food Safety Authority
core   +1 more source

Detection of Different Pesticide Residues in Seasonal Leafy Vegetables of North Bengal Region, Bangladesh

open access: yesPublic Health Challenges, Volume 5, Issue 2, June 2026.
FTIR spectroscopy detected multiple pesticide residues—thiamethoxam, carbendazim, mancozeb + metalaxyl, and dimethoate—in commonly consumed leafy vegetables from North Bengal, Bangladesh. These findings highlight potential food safety risks and emphasize the need for regular monitoring and safer pesticide management practices.
Md. Mejbah Uddin Mithu   +3 more
wiley   +1 more source

Reasoned opinion on the review of the existing maximum residue levels (MRLs) for quinoclamine according to Article 12 of Regulation (EC) No 396/2005

open access: yes, 2013
According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide active substance quinoclamine.
European Food Safety Authority
core   +1 more source

Feasibility of Crosshole Seismic Tomography for Monitoring In Situ CO2 Mineral Storage in Basalts: A Rock Physics‐ and Seismic Modeling Study

open access: yesGeochemistry, Geophysics, Geosystems, Volume 27, Issue 6, June 2026.
Abstract In situ CO2 mineral storage is gaining increasing attention as a carbon capture and storage (CCS) technology to reduce anthropogenic CO2 emissions. So far, in situ CO2 mineral storage projects have been monitored predominantly using fluid‐ and isotope geochemical methods.
Jonas Simon Junker   +4 more
wiley   +1 more source

Reasoned opinion on the review of the existing maximum residue levels (MRLs) for indolylbutyric acid according to Article 12 of Regulation (EC) No 396/2005

open access: yes, 2012
According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the Maximum Residue Levels (MRLs) currently established at European level for the pesticide active substance indolylbutyric acid.
European Food Safety Authority
core   +1 more source

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

open access: yesActa Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik   +44 more
wiley   +1 more source

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