Results 121 to 130 of about 1,826,338 (237)

Noise control in gene regulatory networks with negative feedback

, 2016
Genes and proteins regulate cellular functions through complex circuits of biochemical reactions. Fluctuations in the components of these regulatory networks result in noise that invariably corrupts the signal, possibly compromising function.
Hinczewski, Michael, Thirumalai, D.
core   +1 more source

Nonsense-mediated mRNA decay at the crossroads of many cellular pathways

BMB Reports, 2017
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC ...
F. Lejeune
semanticscholar   +1 more source

Interplay between coronavirus, a cytoplasmic RNA virus, and nonsense-mediated mRNA decay pathway

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Coronaviruses (CoVs) are important pathogens for humans and domestic animals. The development of effective countermeasures against CoVs requires an understanding of the host pathways that regulate viral gene expression and the viral ...
M. Wada, K. Lokugamage, Keisuke Nakagawa, Krishna Shankara Narayanan, S. Makino   +4 more
semanticscholar   +1 more source

mRNA Decay [PDF]

Molecular Cell, 2003
Long, Roy M, McNally, Mark T
openaire   +1 more source

Attenuation of transcriptional bursting in mRNA transport

, 2009
Due to the stochastic nature of biochemical processes, the copy number of any given type of molecule inside a living cell often exhibits large temporal fluctuations.
Izaurralde E, Lei-han Tang, Li-ping Xiong, Van Kampen N G, Yu-qiang Ma   +4 more
core   +1 more source

Simulation based sequential Monte Carlo methods for discretely observed Markov processes [PDF]

, 2014
Parameter estimation for discretely observed Markov processes is a challenging problem. However, simulation of Markov processes is straightforward using the Gillespie algorithm.
Neal, Peter
core  

lncRNAs transactivate Staufen1-mediated mRNA decay by duplexing with 3'UTRs via Alu elements

Nature, 2010
Staufen 1 (STAU1)-mediated messenger RNA decay (SMD) involves the degradation of translationally active mRNAs whose 3′-untranslated regions (3′ UTRs) bind to STAU1, a protein that binds to double-stranded RNA.
Chenguang Gong, L. Maquat
semanticscholar   +1 more source

UPF1 regulates mRNA stability by sensing poorly translated coding sequences

Cell Reports
Summary: Post-transcriptional mRNA regulation shapes gene expression, yet how cis-elements and mRNA translation interface to regulate mRNA stability is poorly understood.
Damir Musaev, Mario Abdelmessih, Charles E. Vejnar, Valeria Yartseva, Linnea A. Weiss, Ethan C. Strayer, Carter M. Takacs, Antonio J. Giraldez   +7 more
doaj   +1 more source

SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA.

PLoS ONE, 2013
mRNAs targeted by endonuclease decay generally disappear without detectable decay intermediates. The exception to this is nonsense-containing human β-globin mRNA, where the destabilization of full-length mRNA is accompanied by the cytoplasmic ...
Roshan Mascarenhas, Julie A Dougherty, Daniel R Schoenberg   +2 more
doaj   +1 more source

Ubiquitous accumulation of 3′ mRNA decay fragments in Saccharomyces cerevisiae mRNAs with chromosomally integrated MS2 arrays

RNA: A publication of the RNA Society, 2016
The binding of MS2-GFP protein to arrays of MS2 sites in yeast mRNAs has been used extensively to visualize mRNA localization. We previously reported that arrays of MS2 sites bound by MS2 protein could inhibit Xrn1p and lead to the accumulation of 3 ...
Jennifer F. Garcia, R. Parker
semanticscholar   +1 more source