Results 231 to 240 of about 87,391 (262)

Control of mRNA processing and decay in prokaryotes

Genetica, 1994
Post-transcriptional mechanisms operate in regulation of gene expression in bacteria, the amount of a given gene product being also dependent on the inactivation rate of its own message. Moreover, segmental differences in mRNA stability of polycistronic transcripts may be responsible for differential expression of genes clustered in operons.
ALIFANO, Pietro, BRUNI CB, CARLOMAGNO MS
openaire   +4 more sources

Regulation of nonsense‐mediated mRNA decay

WIREs RNA, 2012
AbstractNonsense‐mediated mRNA decay (NMD) is a highly conserved pathway that was originally identified as a RNA surveillance mechanism that degrades aberrant mRNAs harboring premature termination (nonsense) codons. Recently, it was discovered that NMD also regulates normal gene expression.
Lulu, Huang, Miles F, Wilkinson
openaire   +2 more sources

Analyzing mRNA decay in saccharomyces cerevisiae

2002
Publisher Summary This chapter discusses the process of mRNA decay in Saccharomyces cerevisiae ( S. cerevisiae ) and describes the experimental procedures that can be used to determine the rates of mRNA turnover in yeast, as well as the specific pathway of degradation for any given transcript.
Michelle A, Steiger, Roy, Parker
openaire   +2 more sources

Mechanistic Modeling of Prokaryotic mRNA Decay

Journal of Theoretical Biology, 1997
A mechanistic model of gene expression was developed to test three prevailing and sliding prokaryotic mRNA decay theories: ribosome protection of mRNA from endonucleases, 5' binding and sliding of endonucleases on mRNA, and hybrid 5' binding/ribosome protection.
T A, Carrier, J D, Keasling
openaire   +2 more sources

When mRNA translation meets decay

Biochemical Society Transactions, 2017
Messenger RNA (mRNA) translation and mRNA degradation are important determinants of protein output, and they are interconnected. Previously, it was thought that translation of an mRNA, as a rule, prevents its degradation. mRNA surveillance mechanisms, which degrade mRNAs as a consequence of their translation, were considered to be exceptions to this ...
Bicknell, Alicia A., Ricci, Emiliano P.
openaire   +4 more sources

Mechanisms of mRNA decay in bacteria: a perspective

Gene, 1988
Messenger RNA decay plays an important role in prokaryotic gene expression. The disparate stabilities of bacterial messages in vivo are a consequence of their differential susceptibility to degradation by cellular endoribonucleases and 3' -exoribonucleases, which in turn results from differences in mRNA sequence and structure.
J G, Belasco, C F, Higgins
openaire   +2 more sources

Nonsense-mediated mRNA Decay in Yeast

1994
Publisher Summary This chapter describes the mRNA-destabilizing phenomenon as nonsense-mediated mRNA decay, and reviews the cis-acting sequences and trans-acting factors that comprise this pathway in the yeast Saccharomyces cerevisiae. The observation that premature translation termination can promote rapid mRNA decay is just one in a large set of ...
Peltz, Stuart W., He, Feng, Welch, Ellen Marie, Jacobson, Allan   +3 more
openaire   +3 more sources

mRNA Decay and Processing

2014
Since there have been several extensive reviews of mRNA decay within the last several years, this chapter focuses on issues that have not been completely resolved. These include the importance of RNA structural elements in mRNA decay, the existence and function of multiprotein mRNA decay complexes, the role of polyadenylation in mRNA decay, the ...
openaire   +1 more source

Cytoplasmic organelles on the road to mRNA decay

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
Localization of both mRNAs and mRNA decay factors to internal membranes of eukaryotic cells provides a means of coordinately regulating mRNAs with common functions as well as coupling organelle function to mRNA turnover. The classic mechanism of mRNA localization to membranes is the signal sequence-dependent targeting of mRNAs encoding membrane and ...
Weil, Dominique, Hollien, Julie
openaire   +3 more sources

The EDC4‐XRN1 interaction controls P‐body dynamics to link mRNA decapping with decay

EMBO Journal, 2023
William R Brothers, Sam Kajjo, Marc R Fabian   +2 more
exaly