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Insights From Nonsense-Mediated mRNA Decay for Prognosis in Homologous Recombination-Deficient Ovarian Cancer. [PDF]
Cancer SciHan L +8 more
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Spatially regulated mRNA decay sharpens expression patterns in the Drosophila embryo
Love JC +4 more
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The highways and byways of mRNA decay
Nature Reviews Molecular Cell Biology, 2007When considering the control of gene expression, the focus has traditionally been on transcriptional regulation. Recently, however, the large contribution made by mRNA decay has become difficult to ignore. Large-scale analyses indicate that as many as half of all changes in the amounts of mRNA in some responses can be attributed to altered rates of ...
Nicole L Garneau +2 more
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Molecular and General Genetics MGG, 1978
Degradation of messenger RNA from the lactose operon (lac mRNA) was measured during the inhibition of protein synthesis by chloramphenicol (CM) or of translation-initiation by kasugamycin (KAS). With increasing CM concentration mRNA decay becomes slower, but there is no direct proportionality between rates of chemical decay and polypeptide synthesis ...
E, Schneider, M, Blundell, D, Kennell
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Degradation of messenger RNA from the lactose operon (lac mRNA) was measured during the inhibition of protein synthesis by chloramphenicol (CM) or of translation-initiation by kasugamycin (KAS). With increasing CM concentration mRNA decay becomes slower, but there is no direct proportionality between rates of chemical decay and polypeptide synthesis ...
E, Schneider, M, Blundell, D, Kennell
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Biochemical Society Transactions, 2008
Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes
Jikai, Wen, Saverio, Brogna
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Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes
Jikai, Wen, Saverio, Brogna
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Regulation of mRNA Decay in Bacteria
Annual Review of Microbiology, 2016Gram-negative and gram-positive bacteria use a variety of enzymatic pathways to degrade mRNAs. Although several recent reviews have outlined these pathways, much less attention has been paid to the regulation of mRNA decay. The functional half-life of a particular mRNA, which affects how much protein is synthesized from it, is determined by a ...
Bijoy K, Mohanty, Sidney R, Kushner
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Molecular Microbiology, 2006
SummaryAlthough plasmid‐borne and chromosomal toxin–antitoxin (TA) operons have been known for some time, the recent identification of mRNA as the target of at least two different classes of toxins has led to a dramatic renewal of interest in these systems as mediators of stress responses.
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SummaryAlthough plasmid‐borne and chromosomal toxin–antitoxin (TA) operons have been known for some time, the recent identification of mRNA as the target of at least two different classes of toxins has led to a dramatic renewal of interest in these systems as mediators of stress responses.
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Trends in Biotechnology, 1990
• Clarifying complementary roles for natural and genetically manipu- lated microorganisms. • Assuring that bioremediation does not produce toxic inter- mediates or hazardous end products in treated environments. • Broadening the range of priority chemicals treatable by biological processes.
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• Clarifying complementary roles for natural and genetically manipu- lated microorganisms. • Assuring that bioremediation does not produce toxic inter- mediates or hazardous end products in treated environments. • Broadening the range of priority chemicals treatable by biological processes.
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Measuring mRNA Decay with Roadblock‐qPCR
Current Protocols, 2022AbstractThe control of mRNA stability is fundamental to gene regulation, and a deeper understanding of this post‐transcriptional regulatory step can provide key insights into gene function. Measuring mRNA half‐lives directly, however, is challenging.
Maegan J, Watson, Carson C, Thoreen
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CYP3A5 mRNA Degradation by Nonsense-Mediated mRNA Decay
Molecular Pharmacology, 2005The total CYP3A5 mRNA level is significantly greater in carriers of the CYP3A5*1 allele than in CYP3A5*3 homozygotes. Most of the CYP3A5*3 mRNA includes an intronic sequence (exon 3B) containing premature termination codons (PTCs) between exons 3 and 4.
Florent, Busi, Thierry, Cresteil
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