Results 1 to 10 of about 368,275 (298)

Induction of WNT16 via Peptide-mRNA Nanoparticle-Based Delivery Maintains Cartilage Homeostasis [PDF]

Pharmaceutics, 2020
Osteoarthritis (OA) is a progressive joint disease that causes significant disability and pain and for which there are limited treatment options. We posit that delivery of anabolic factors that protect and maintain cartilage homeostasis will halt or ...
Huimin Yan, Ying Hu, Antonina Akk, Muhammad Farooq Rai, Hua Pan, Samuel A. Wickline, Christine T.N. Pham   +6 more
doaj   +3 more sources

Polyester materials for mRNA delivery

Exploration of Targeted Anti-tumor Therapy, 2022
Messenger RNA (mRNA) has recently made important progress in clinical implementation, offering a promising therapeutic option for infectious disease and cancer. However, the nature of mRNA molecules rendered them poorly bioavailable and unstable in vivo,
Wang Chen, Yonghui Ma, Xiaoxuan Liu, Dandan Zhu   +3 more
doaj   +3 more sources

mRNA delivery in cancer immunotherapy

Acta Pharmaceutica Sinica B, 2023
Messenger RNA (mRNA) has drawn much attention in the medical field. Through various treatment approaches including protein replacement therapies, gene editing, and cell engineering, mRNA is becoming a potential therapeutic strategy for cancers.
Yichen Zhong, Shi Du, Yizhou Dong
doaj   +3 more sources

mRNA delivery systems 2.0: Engineering extrahepatic delivery for non-vaccine therapeutics [PDF]

Materials Today Bio
Recent breakthroughs in mRNA therapeutics have transformed vaccine development, largely powered by lipid nanoparticle (LNP) based delivery systems. However, these systems exhibit a strong hepatic tropism, making them suboptimal for targeting extrahepatic
Manoj Dalabehera, Arnab Ghosh, Satyajit Mohanty, Dinesh Kumar Chellappan, Shubham Chaudhari, Yogita Ale, Neelam Poonia, Rudra Narayan Subudhi, Manmeet Kaur Khanna, Hae Gyun Lim   +9 more
doaj   +2 more sources

Recent Advances in mRNA Delivery Systems for Cancer Therapy [PDF]

Advanced Science
mRNA therapy is a promising approach in oncology, offering innovative applications such as tumor vaccines, protein replacement therapy, cell therapy, and gene therapy.
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
doaj   +2 more sources

Nonviral targeted mRNA delivery: principles, progresses, and challenges [PDF]

MedComm
Messenger RNA (mRNA) therapeutics have garnered considerable attention due to their remarkable efficacy in the treatment of various diseases. The COVID‐19 mRNA vaccine and RSV mRNA vaccine have been approved on the market.
Xi He, Guohong Li, Letao Huang, Haixing Shi, Sha Zhong, Siyu Zhao, Xiangyu Jiao, Jinxiu Xin, Xiaoling Yin, Shengbin Liu, Zhongshan He, Mengran Guo, Chunli Yang, Zhaohui Jin, Jun Guo, Xiangrong Song   +15 more
doaj   +2 more sources

A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations [PDF]

Molecular Therapy: Nucleic Acids
Messenger RNA (mRNA) therapeutics show considerable promise but face delivery challenges, as effective cytosolic entry and subsequent translation are normally limited by endosomal entrapment.
Alfredo D. Smart, Merryn E. Hughes, Angela Downie Ruiz Velasco, Naoto Hori, Snow Stolnik, Catherine L. Jopling   +5 more
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Efficient mRNA Delivery with mRNA Lipoplexes Prepared Using a Modified Ethanol Injection Method

Pharmaceutics, 2023
Messenger RNA (mRNA)-based therapies are a novel class of therapeutics used in vaccination and protein replacement therapies for monogenic diseases.
Min Tang, Ayane Sagawa, Nodoka Inoue, Satomi Torii, Kana Tomita, Yoshiyuki Hattori   +5 more
doaj   +1 more source

PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials

Pharmaceutics, 2021
Messenger RNA (mRNA) delivery strategies are required to protect biologically fragile mRNA from ribonuclease (RNase) attacks to achieve efficient therapeutic protein expression.
Naoto Yoshinaga, Mitsuru Naito, Yoshihiro Tachihara, Eger Boonstra, Kensuke Osada, Horacio Cabral, Satoshi Uchida   +6 more
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Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery

Pharmaceutics, 2023
Directly injecting naked or lipid nanoparticle (LNP)-encapsulated modified mRNA (modRNA) allows rapid and efficient protein expression. This non-viral technology has been used successfully in modRNA vaccines against SARS-CoV-2.
Magdalena M. Żak, Keerat Kaur, Jimeen Yoo, Ann Anu Kurian, Matthew Adjmi, Gayatri Mainkar, Seonghun Yoon, Lior Zangi   +7 more
doaj   +1 more source