Results 181 to 190 of about 368,275 (298)

Virus-Inspired mRNA Delivery Vehicle Enabled by a Multilayered Nucleic Acid Nanocapsule. [PDF]

ACS Nano
Pal S, Singla D, Canete RC, Darkwah JB, Cannata JN, Hunte ML, Penales IB, Szczepanek SM, Ducongé F, Smilowitz HM, Rouge JL.   +10 more
europepmc   +1 more source

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells. [PDF]

Adv Mater
Trines MM, Hoorn D, Hofstraat SRJ, Zwolsman RC, Anbergen T, Versteeg I, van Elsas Y, Deckers J, Hendrikx MMA, Kleuskens T, Darwish YB, Ros GWB, Dijkstra SF, Priem B, Timmers M, Fransen PM, Pouderoijen MJ, de Waal BFM, Meijer EW, Beldman TJ, Toner YC, Kluza E, Mulder WJM, Janssen HM, van der Meel R.   +24 more
europepmc   +1 more source

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun, XueBo Wei, ZhuoYang Song, JunJun Luo, JingYi Ye, YinNan Zhang, LiFei Zhu, Jie Gao, Hongyu Zhang, Hong Zhu, Xin Wang, Ke Xu   +11 more
wiley   +1 more source

Ionizable guanidine-based lipid nanoparticle for targeted mRNA delivery and cancer immunotherapy. [PDF]

Sci Adv
Zhang H, Liu D, Yang K, Liang Z, Li M.
europepmc   +1 more source

Nb2C‐Reinforced Hydrogel Microneedle as Dual ROS‐Scavenging Platform to Promote Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
An advanced microneedle patch integrating niobium carbide nanosheets and curcumin is engineered for diabetic wound healing. The system enables dual ROS scavenging and NIR‐enhanced antimicrobial activity, effectively rebalancing the oxidative microenvironment, promoting macrophage repolarization and angiogenesis, and accelerating full‐thickness wound ...
Zhi Zheng, Heyan Huang, Xiangru Chen, Jie Fu, Zhiwei Sun, Mengjuan Tao, Jianwei Mao, Fei Zhang, Zhou Wan, Yuan Li, Dingan Wu, Chuchao Zhou, Yanqing Yang   +12 more
wiley   +1 more source

Developing Biomaterial-Based mRNA Delivery System for Lung Disease Treatment. [PDF]

Adv Sci (Weinh)
Gu Q, Xue H, Liu Z, Rao J, Zeng L, Zhang C, Lei L, Shi L.   +7 more
europepmc   +1 more source

Ultrasound‐Triggered Nanobubbles for Endothelial‐Targeted Drug Delivery in the Detection and Treatment of Doxorubicin‐Induced Cardiotoxicity

Advanced Healthcare Materials, EarlyView.
The DA/VTP‐NBs selectively recognized cardiac ECs damaged by DIC and achieved cell‐level targeted imaging. Then US‐triggered controlled release successfully enabled the release of DAPA within the DA/VTP‐NBs at the site of injury. This precise on‐demand drug release approach amplifies a series of localized therapeutic effects through the mtDNA‐mediated ...
Jun Zhang, Yi Ling, Xin Li, Deng Liu, Li Dong, Xuemei Chen, Yingxin Sun, Yongning Shang, Yanli Guo   +8 more
wiley   +1 more source

Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor-Targeted Therapy. [PDF]

Angew Chem Int Ed Engl
Chen P, Hu G, Nakashima Y, Xu Z, Watanabe T, Kondo S, Kovács E, Cabral H.   +7 more
europepmc   +1 more source

Dual target gene therapy to EML4-ALK NSCLC by a gold nanoshell-based system [PDF]

, 2018
Achilefu, Samuel, Gu, Yueqiing, Li, Siwen, Liu, Yuxi, Rui, Yalan, Tang, Liping   +5 more
core   +2 more sources