Results 11 to 20 of about 368,275 (298)
Lipid carriers for mRNA delivery
Acta Pharmaceutica Sinica B, 2023 Messenger RNA (mRNA) is the template for protein biosynthesis and is emerging as an essential active molecule to combat various diseases, including viral infection and cancer.
Wanting Zhang +6 more
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Cell-Derived Vesicles for mRNA Delivery
Pharmaceutics, 2022 The clinical translation of messenger mRNA (mRNA)-based therapeutics requires safe and effective delivery systems. Although considerable progress has been made on the development of mRNA delivery systems, many challenges, such as the dose-limiting ...
Zhenghua Li, Zhen Liu, Jiacai Wu, Bin Li
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Targeting strategies for mRNA delivery
Materials Today Advances, 2022 mRNA gene therapy has recently emerged as a candidate to enable multiple therapeutic applications including protein replacement therapy, vaccine immunology, and regenerative medicine.
Randall A. Meyer +4 more
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Nanomaterial Delivery Systems for mRNA Vaccines [PDF]
Vaccines, 2021 The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the development of lipid nanoparticle delivery systems that not only efficiently express the mRNA-encoded immunogen after intramuscular injection, but also play roles as ...
Michael D. Buschmann +5 more
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Charge-Complementary Polymersomes for Enhanced mRNA Delivery
Pharmaceutics, 2023 Messenger RNA (mRNA) therapies have emerged as potent and personalized alternatives to conventional DNA-based therapies. However, their therapeutic potential is frequently constrained by their molecular instability, susceptibility to degradation, and ...
HakSeon Kim +5 more
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Delivery Strategies for mRNA Vaccines [PDF]
Pharmaceutical Medicine, 2022 The therapeutic potential for messenger RNA (mRNA) in infectious diseases and cancer was first realized almost three decades ago, but only in 2018 did the first lipid nanoparticle-based small interfering RNA (siRNA) therapy reach the market with the United States Food and Drug Administration (FDA) approval of patisiran (Onpattro™) for hereditary ATTR ...
Sivakumar Ramachandran +2 more
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mRNA vaccines: A matter of delivery [PDF]
EClinicalMedicine, 2021 Yuhong Cao, George F. Gao
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mRNA Vaccine Platform: mRNA Production and Delivery
Russian Journal of Bioorganic Chemistry, 2023 Vaccination is the most efficient way to prevent infectious diseases. mRNA-based vaccines is a new approach to vaccine development, which have several very useful advantages over other types of vaccines. Since mRNA encodes only the target antigen there is no potential risk of infection as in the case with attenuated or inactivated pathogens.
Litvinova, V. R. +3 more
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Biomaterials for mRNA delivery [PDF]
Biomaterials Science, 2015 Schematic representation of various biomaterial-based systems for mRNA delivery: (a) protamine–mRNA complex; (b) lipid nanoparticle; (c) lipid nanoparticle with inorganic compounds (e.g.apatite); (d) cationic polymeric nanoparticle; (e) lipid–polymer hybrid nanoparticles including (i) mRNA–polymer complex core surrounded by a lipid shell and (ii ...
Mohammad Ariful, Islam +5 more
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A Combinatorial Library of Lipid Nanoparticles for Cell Type‐Specific mRNA Delivery
Advanced Science, 2023 Ionizable lipid‐based nanoparticles (LNPs) are the most advanced non‐viral drug delivery systems for RNA therapeutics and vaccines. However, cell type‐specific, extrahepatic mRNA delivery is still a major hurdle, hampering the development of novel ...
Gonna Somu Naidu +10 more
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