Results 191 to 200 of about 368,275 (298)

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, EarlyView.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source

Lipid nanoparticles for mRNA delivery in brain via systemic administration. [PDF]

Sci Adv
Cao D, Hou X, Wang C, Wang S, Liu Z, Tian M, Guo K, Li H, Kang DD, Zhong Y, Xue Y, Yu C, Deng B, Dong Y.   +13 more
europepmc   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Nanobody-Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo. [PDF]

Adv Healthc Mater
Escudé Martinez de Castilla P, Verdi V, de Voogt W, Estapé Sentí M, Koekman AC, Rietveld J, van Kempen S, Yang Q, van Merris J, Jenster G, van Royen ME, Fens MH, Kooijmans SAA, van Weerden WM, van Niel G, Vader P, Schiffelers RM.   +16 more
europepmc   +1 more source

High‐Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting

Advanced Materials, EarlyView.
A DNA barcoding system enables high‐throughput in vivo screening of mitochondrial‐targeting gold nanoparticles. Thirty nanoparticle types with varied shapes, sizes, and ligands are individually barcoded and pooled. The pooled library is administered to tumor‐bearing mice, and barcodes retrieved from tumor mitochondria are amplified and sequenced to ...
Xingyue Huang, Xuehao Tian, Kuei Chen, Yang Wu, ChenCheng Xue, Yingjie Quek, Jessalyn Low, Arun Kumar, Andy Tay   +8 more
wiley   +1 more source

mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model. [PDF]

NPJ Vaccines
Wu NR, Beutler N, Hu X, Skog PD, Liguori A, Flores-Garcia Y, Maiorino L, Terada S, Lu D, Lai YC, Ndihokubwayo J, Schiffner T, Cottrell CA, Eskandarzadeh S, Alavi N, Kubitz M, Phelps N, Tingle R, Hodges S, Youhanna JE, Amirzehni S, Irvine DJ, Himansu S, Zavala F, Rogers TF, Burton DR, Schief WR.   +26 more
europepmc   +1 more source

Protein production is an early biomarker for RNA‐targeted therapies [PDF]

, 2018
Alex, Jacob, Barthélemy, Nicolas, Bateman, Randall J, Bollinger, James G, Cole, Tracy, Kordasiewicz, Holly B, Miller, Timothy M, Sato, Chihiro, Schoch, Kathleen M, Self, Wade K, Swayze, Eric   +10 more
core   +2 more sources

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Investigating the Design of ssPalmO-Derived Lipid Nanoparticles for mRNA Delivery Applications Using Molecular Dynamics Simulations. [PDF]

ACS Omega
Barange A, Luwang MN, Meena SK.
europepmc   +1 more source