Results 251 to 260 of about 368,275 (298)

A Bioactive Lipid Nanoparticle Integrating Arachidonic Acid Enables High-Efficiency mRNA Delivery and Potent CAR-Macrophage Engineering. [PDF]

Int J Mol Sci
Fu J, Zhang Y, Lv Y, Li R, Gu H, Yang J.
europepmc   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery. [PDF]

Adv Healthc Mater
Samaridou E, Simon J, Beck-Broichsitter M, Davidson G, Levkin PA.   +4 more
europepmc   +1 more source

Formulation-Driven Optimization of PEG-Lipid Content in Lipid Nanoparticles for Enhanced mRNA Delivery In Vitro and In Vivo. [PDF]

Pharmaceutics
Liu W, Zhang M, Lv H, Yang C.
europepmc   +1 more source

Mannose-Conjugated Cholesterol Containing Lipid Nanoparticles for Active Targeted mRNA Delivery to Liver Sinusoidal Endothelial and Kupffer Cells. [PDF]

Bioconjug Chem
Kim Y, Chatterjee S, Robertson AL, Guerrero ED, Vaidya A, Wang X, Lee SM, Wei J, Miller WE, Farbiak L, Siegwart DJ.   +10 more
europepmc   +1 more source

Invisible medical records and mRNA delivery via microneedles: A leap toward equitable healthcare. [PDF]

Innovation (Camb)
Zheng Y, Zhu L, Su X, Niu J, Wang J.
europepmc   +1 more source

Reducing Complexity in Lipid Nanoparticles: Three-Component Zwitterionic Amino Lipids for Targeted Extrahepatic mRNA Delivery. [PDF]

ACS Biomater Sci Eng
Robinson JJ, Zhang D, Basak P, Vaidya A, Chatterjee S, Bian X, Kim M, Lian X, Sun Y, Guerrero E, Wang X, Lee SM, Liu S, Gong J, Tiwari M, Babanyinah GK, Stefan MC, Farbiak L, Siegwart DJ.   +18 more
europepmc   +1 more source

Lipid nanoparticles for mRNA delivery [PDF]

Nature Reviews Materials, 2021
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release.
Xucheng Hou, Robert Samuel Langer Jr, Yi-Zhou Dong   +2 more
exaly   +3 more sources

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Non-liver mRNA Delivery

Accounts of Chemical Research, 2021
mRNA drugs can preempt infectious disease and treat Mendelian disorders, such as sickle cell anemia, muscular dystrophy, and cystic fibrosis, as well as autoimmunity and cancer. The three major therapeutic areas for which mRNA delivery is currently being explored are antigen production, including the COVID-19 vaccine, protein replacement therapy, and ...
David Loughrey, James E. Dahlman
openaire   +2 more sources

Optimal delivery strategies for nanoparticle-mediated mRNA delivery

Journal of Materials Chemistry B, 2023
The nanoparticle-bio interaction occurs at overall stages during thein vivojourney of nanoparticle-mRNA formulations. Optimal delivery strategies based nano-bio interaction is dedicated for an ideal mRNA delivery system.
Xiaoyan Li, Xiaocui Guo, Mingdi Hu, Rong Cai, Chunying Chen   +4 more
openaire   +2 more sources