Results 261 to 270 of about 368,275 (298)

Intradermal delivery of mRNA using cryomicroneedles

Acta Biomaterialia, 2022
Microneedles can realize the intradermal and transdermal delivery of drugs. However, most conventional microneedles made of metal, polymer and ceramics are unsuitable for the delivery of mRNA drugs that are fragile and temperature-sensitive. This study explores the usage of cryomicroneedles (CryoMNs) for the intradermal delivery of mRNA molecules ...
Jinming Yu, Chaiyaporn Kuwentrai, Hua-Rui Gong, Renhao Li, Bao-zhong Zhang, Xuansheng Lin, Xiaolei Wang, Jian-Dong Huang, Chenjie Xu   +8 more
openaire   +2 more sources

Therapeutic mRNA delivery to leukocytes

Journal of Controlled Release, 2019
In the past few years mRNA molecules have become an attractive class of new drugs with numerous opportunities. mRNA therapeutics holds great potential for the treatment of a variety of diseases and is an emerging field both in academia and in the pharma industry.
Granot-Matok, Yasmin, Kon, Edo, Dammes, Niels, Mechtinger, Gilad, Peer, Dan   +4 more
openaire   +2 more sources

mRNA delivery technologies: Toward clinical translation

2022
Messenger RNA (mRNA)-therapies have recently taken a huge step toward clinic thanks to the first mRNA-based medicinal products marketed. mRNA features for clinical purposes are improved by chemical modifications, but the inclusion in a delivery system is a regular requirement.
Itziar, Gómez-Aguado, Julen, Rodríguez-Castejón, Marina, Beraza-Millor, Alicia, Rodríguez-Gascón, Ana, Del Pozo-Rodríguez, María Ángeles, Solinís   +5 more
openaire   +2 more sources

Delivery of synthetic mRNAs for tissue regeneration

Advanced Drug Delivery Reviews, 2021
In recent years, nucleic acid-based therapeutics have gained increasing importance as novel treatment options for disease prevention and treatment. Synthetic messenger RNAs (mRNAs) are promising nucleic acid-based drugs to transiently express desired proteins that are missing or defective. Recently, synthetic mRNA-based vaccines encoding viral proteins
Heidrun, Steinle, Josefin, Weber, Sandra, Stoppelkamp, Katharina, Große-Berkenbusch, Sonia, Golombek, Marbod, Weber, Tuba, Canak-Ipek, Sarah-Maria, Trenz, Christian, Schlensak, Meltem, Avci-Adali   +9 more
openaire   +2 more sources

Current prospects for mRNA gene delivery

European Journal of Pharmaceutics and Biopharmaceutics, 2009
Replication-deficient viruses have been used most successfully in the field of gene therapy because of their high transfection efficiency. However, the risk of insertional mutagenesis and induction of unwanted immune responses remains still critical for their safe application.
Ayako, Yamamoto, Michael, Kormann, Joseph, Rosenecker, Carsten, Rudolph   +3 more
openaire   +2 more sources

Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

Advanced Materials, 2023
AbstractMessenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly scalable therapeutic approach that involves technologies for both mRNA itself and the delivery vehicle. Although there are some unique challenges for different applications of mRNA therapy, a common challenge for all mRNA therapeutics is the transport of mRNA into ...
Pei Huang, Hongzhang Deng, Changrong Wang, Yongfeng Zhou, Xiaoyuan Chen   +4 more
openaire   +2 more sources

Novel Vectors and Administrations for mRNA Delivery

Small, 2023
AbstractmRNA therapy has shown great potential in infectious disease vaccines, cancer immunotherapy, protein replacement therapy, gene editing, and other fields due to its central role in all life processes. However, mRNA is challenging to pass through the cell membrane due to its significant negative charges and degradation from RNase, so the key to ...
Chenghai Bai, Chen Wang, Yuan Lu
openaire   +2 more sources

Polymers for mRNA Delivery

WIREs Nanomedicine and Nanobiotechnology
ABSTRACTmRNA delivery has emerged as a transformative approach in biotechnology and medicine, offering a versatile platform for the development of novel therapeutics. Unlike traditional small molecule drugs or protein‐based biologics, mRNA therapeutics have the unique ability to direct cells to generate therapeutic proteins, allowing for precise ...
Hui Wang, Yiyun Cheng
openaire   +2 more sources

mRNA delivery using non-viral PCL nanoparticles

Biomaterials Science, 2015
GFP mRNA-protamine complex encapsulated poly(ε-caprolactone) (PCL) non-viral nanoparticles are proposed for the intracellular delivery of mRNA molecules.
I E Palamà, B Cortese, S D'Amone, G Gigli   +3 more
openaire   +4 more sources

Interaction design in mRNA delivery systems

Journal of Controlled Release
Following the coronavirus disease 2019 (COVID-19) pandemic, mRNA technology has made significant breakthroughs, emerging as a potential universal platform for combating various diseases. To address the challenges associated with mRNA delivery, such as instability and limited delivery efficacy, continuous advancements in genetic engineering and ...
Mengyao, Yu, Lixin, Lin, Dezhong, Zhou, Shuai, Liu   +3 more
openaire   +2 more sources