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Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy
Molecules, 2022 Messenger RNA (mRNA) is being developed by researchers as a novel drug for the treatment or prevention of many diseases. However, to enable mRNA to fully exploit its effects in vivo, researchers need to develop safer and more effective mRNA delivery ...
Hong-Li Wang, Zhi-Gang Wang, Shu-Lin Liu
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Fluorescence-based quantification of messenger RNA and plasmid DNA decay kinetics in extracellular biological fluids and cell extracts [PDF]
, 2020 Extracellular and intracellular degradation of nucleic acids remains an issue in non-viral gene therapy. Understanding biodegradation is critical for the rational design of gene therapeutics in order to maintain stability and functionality at the target ...
Braeckmans, Kevin +6 more
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mRNA Vaccine Delivery Using Lipid Nanoparticles [PDF]
Therapeutic Delivery, 2016 mRNA vaccines elicit a potent immune response including antibodies and cytotoxic T cells. mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy applications, but also have great potential as prophylactic vaccines. Efficient delivery of mRNA vaccines will be key for their success and translation to the clinic. Among potential
Reichmuth, Andreas Michael +4 more
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Iron Oxide Nanoparticle-Mediated mRNA Delivery to Hard-to-Transfect Cancer Cells
Pharmaceutics, 2023 mRNA-based therapeutics have emerged as a promising strategy for cancer treatment. However, the effective delivery of mRNA into hard-to-transfect cancer cells remains a significant challenge.
Jianxi Huang +7 more
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Engineering nanoparticle toolkits for mRNA delivery
Advanced Drug Delivery Reviews, 2023 The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal drug candidate, holding great potential to revolutionize the way we approach medicine. The unique characteristics of mRNA, as well as its customizable biomedical functions, call for the rational design of delivery systems to protect and transport mRNA molecules.
Bing Sun +6 more
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Development and Delivery Systems of mRNA Vaccines [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Since the outbreak of SARS-CoV-2, mRNA vaccine development has undergone a tremendous drive within the pharmaceutical field. In recent years, great progress has been made into mRNA vaccine development, especially in individualized tumor vaccines. mRNA vaccines are a promising approach as the production process is simple, safety profiles are better than
Liu, Tiancai +2 more
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Ionizable Lipid Nanoparticles for mRNA Delivery
Advanced NanoBiomed Research, 2023 Therapeutics based on messenger RNA (mRNA) have become a promising class of methods for various diseases’ treatments in recent years. The safe and effective delivery of mRNA into target cells is the premise of the clinical translation of mRNA. Due to the
Xuefeng Tang, Ying Zhang, Xiaojun Han
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Human β-Defensin 23 as a Carrier for In Vitro and In Vivo Delivery of mRNA
Pharmaceutics, 2023 The successful application of mRNA therapeutics hinges on the effective intracellular delivery of mRNA both in vitro and in vivo. However, this remains a formidable challenge due to the polyanionic nature, longitudinal shape, and low nuclease resistance ...
Kyoung-Ran Kim +3 more
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Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells. [PDF]
, 2015 The treatment of myocardial infarction is a major challenge in medicine due to the inability of heart tissue to regenerate. Direct reprogramming of endogenous cardiac fibroblasts into functional cardiomyocytes via the delivery of transcription factor ...
Kim, Hyun Jin +5 more
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Inhibition of Xenograft tumor growth by gold nanoparticle-DNA oligonucleotide conjugates-assisted delivery of BAX mRNA. [PDF]
PLoS ONE, 2013 Use of non-biological agents for mRNA delivery into living systems in order to induce heterologous expression of functional proteins may provide more advantages than the use of DNA and/or biological vectors for delivery.
Ji-Hyun Yeom +5 more
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