Results 31 to 40 of about 368,275 (298)

Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system [PDF]

, 2016
DNA-based gene therapy has considerable therapeutic potential, but the challenges associated with delivery continue to limit progress. Messenger RNA (mRNA) has the potential to provide for transient production of therapeutic proteins, without the need ...
A Akinc, A Akinc, A Coppola, A Yamamoto, AJ Geall, AP Cotrim, B Burcovich, B Guild, B Urban-Klein, B Weide, B Yahalom, BL Davidson, C Wolfrum, CW Chen, D Chen, D G Anderson, D Oupicky, DB Rozema, DG Gardner, DJ Siegwart, DM Lynn, DP Bartel, F DeRosa, G Kaur, G Sahay, GC White, GR Sambrano, H Yin, HF Bunn, HF Lin, I Koltover, J Heyes, J Heyes, J McCaskill, J R Dorkin, J Zhang, JF Lee, JH Jeong, JHP Chan, JM Soucie, Jr Broze GJ, K Germer, K J Kauffman, K Karikó, K Love, K Maruyama, KA Howard, KJ Kauffman, KT Love, L Aagaard, L Smith, L Vannucci, L Zangi, LE Mays, LM Alvarez-Salas, M Baba, M Fotin-Mleczek, M Franchini, M Franchini, M Jayaraman, M Oishi, M O’Reilly, M W Heartlein, MA Bartel, ME Davis, MSD Kormann, N Agrawal, N Dias, N Murthy, NBY Tsui, P Fechter, P Giangrande, P Tam, Q Lin, S Daya, S Karve, SC Semple, SD Li, SM Hammond, T Aboul-Fadl, T Gui, T Wirth, TG Park, TK Greene, XB Zhao, Y Dong, Y Dorsett, Y Liu, Y Wang, YYC Tam   +89 more
core   +1 more source

The Delivery of mRNA Vaccines for Therapeutics

Life, 2022
mRNA vaccines have been revolutionary in combating the COVID-19 pandemic in the past two years. They have also become a versatile tool for the prevention of infectious diseases and treatment of cancers.
Nitika, Jiao Wei, Ai-Min Hui
doaj   +1 more source

In vitro and in vivo mRNA delivery using lipid-enveloped pHresponsive polymer nanoparticles [PDF]

, 2011
Biodegradable core−shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based vaccines.
Alexopoulou L., Allen T. M., Anton N., Awasthi S., Bershteyn A., Bettinger T., Biesalski M., Biesheuvel P. M., Blum J. S., Boussif O., Brooking J., Brunner S., Cheng W. W. K., Choksakulnimitr S., Csaba N., Currie E. P. K., Czerkinsky C., Dacey D. M., Daniel G. Kavanagh, Darrell J. Irvine, Denis-Mize K. S., Devalapally H., Febvay S., Fernandez-Urrusuno R., Fischer D., Ganachaud F., Ghosh P., Gitlin L., Grayson A. C. R., Green J. J., Hamann S., Hoerr I., Holmgren J., Hu Y., Hu Y. H., Huang Y. H., Illum L., Irvine A. S., Jennifer Fricke, Juliano R., Kato H., Kavanagh D. G., Koping-Hoggard M., Kyte J. A., Lee J. S., Little S. R., Little S. R., Lomas H., Lynn D. M., Lynn D. M., Malone R. W., Martinon F., McDermont M. R., Miller A. C., Moghimi S. M., Nagamoto T., Ngumbela K. C., Pack D. W., Park T. G., Pascolo S., Pollard H., Probst J., Qiu P., Read M. L., Remaut K., Remaut K., Sharma S., Shenoy D., Shenoy D., Singh M., Slutter B., Sonawane N. D., Steinman R. M., Steinman R. M., Straubinger R. M., Strobel I., Takeda K., Tang D. C., Tenopoulou M., Ulmer J. B., Ulmer J. B., Van Driessche A., Vassilev V. B., Wang C., Wasungu L., Weide B., Weide B., Wightman L., Wolff J. A., Xingfang Su, Zalipsky S., Zohra F. T.   +91 more
core   +1 more source

Nanomedicine-Based Approaches for mRNA Delivery [PDF]

Molecular Pharmaceutics, 2020
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies, including immunotherapy and protein replacement. As mRNA presents no risk of integration into the host genome and does not require nuclear entry for transfection, which allows protein production even in nondividing cells, mRNA-based approaches can be envisioned as safe
Uchida, Satoshi, Perche, Federico, Pichon, Chantal, Cabral, Horacio   +3 more
openaire   +3 more sources

mRNA Delivery Platform Based on Bacterial Outer Membrane Vesicles for Tumor Vaccine

Bio-Protocol, 2023
The rapid display and delivery method for customized tumor mRNA vaccines is limited. Herein, bacteria-derived outer membrane vesicles (OMVs) are employed as an mRNA delivery platform by surface engineering of an RNA-binding protein, L7Ae.
Xiaoyu Gao, Yao Li, Guangjun Nie, Xiao Zhao   +3 more
doaj   +1 more source

Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis. [PDF]

, 2013
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms.
Azzouz, M, Higginbottom, A, Nanou, A, Ning, K, Shaw, P, Valori, CF, Wyles, M   +6 more
core   +1 more source

Optimization of Lipid Nanoformulations for Effective mRNA Delivery

International Journal of Nanomedicine, 2022
Huiling Chen,1 Xuan Ren,2 Shi Xu,3 Dekui Zhang,4,* TiYun Han4,* 1Department of Hematology, Lanzhou University Second Hospital, Lanzhou, People’s Republic of China; 2Department of Endocrinology and Metabolism, Lanzhou University Second Hospital ...
Chen H, Ren X, Xu S, Zhang D, Han T
doaj  

Hydrophobic Optimization of Functional Poly(TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration

Pharmaceutics, 2021
Messenger RNA (mRNA) has generated great attention due to its broad potential therapeutic applications, including vaccines, protein replacement therapy, and immunotherapy.
Xueliang Yu, Shuai Liu, Qiang Cheng, Sang M. Lee, Tuo Wei, Di Zhang, Lukas Farbiak, Lindsay T. Johnson, Xu Wang, Daniel John Siegwart   +9 more
doaj   +1 more source

Oral, nasal and pharyngeal exposure to lipopolysaccharide causes a fetal inflammatory response in sheep. [PDF]

, 2015
BackgroundA fetal inflammatory response (FIR) in sheep can be induced by intraamniotic or selective exposure of the fetal lung or gut to lipopolysaccharide (LPS).
Jobe, Alan H, Kallapur, Suhas G, Kannan, Paranthaman Senthamarai, Kemp, Matthew W, Kramer, Boris W, Maneenil, Gunlawadee, Newnham, John P, Saito, Masatoshi   +7 more
core   +3 more sources

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging [PDF]

, 2006
Small interfering RNA (siRNA) molecules are potent effectors of post-transcriptional gene silencing. Using noninvasive bioluminescent imaging and a mathematical model of siRNA delivery and function, the effects of target-specific and treatment-specific ...
Bartlett, Derek W., Davis, Mark E.
core   +1 more source