Results 51 to 60 of about 368,275 (298)
Nonviral Delivery Systems of mRNA Vaccines for Cancer Gene Therapy
Pharmaceutics, 2022 In recent years, the use of messenger RNA (mRNA) in the fields of gene therapy, immunotherapy, and stem cell biomedicine has received extensive attention.
Yusi Wang, Rui Zhang, Lin Tang, Li Yang
doaj +1 more source
Organochlorine pesticides exposure & preterm birth [PDF]
, 2016 Commento su invito ad uno studio su esposizione fetale a composti ...
Fuggetta, Eliana +2 more
core +3 more sources
Drug Delivery, 2023 Inhalable messenger RNA (mRNA) has demonstrated great potential in therapy and vaccine development to confront various lung diseases. However, few gene vectors could overcome the airway mucus and intracellular barriers for successful pulmonary mRNA ...
Yingying Xu +9 more
doaj +1 more source
Intratumoral delivery of mRNA: Overcoming obstacles for effective immunotherapy [PDF]
OncoImmunology, 2015 The immunosuppressive tumor microenvironment (TME) is a major obstacle in cancer immunotherapy. Therefore, it has gained attention as a target site. mRNA emerged as a versatile drug class for cancer therapy. We reported that intratumoral administration of mRNA encoding the fusokine Fβ2 supports tumor-specific T-cell immunity.
Van Der Jeught, Kevin +3 more
openaire +2 more sources
Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases. [PDF]
, 2016 We examined the efficiency, specificity, and mutational signatures of zinc finger nucleases (ZFNs), transcriptional activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 systems designed to
Bjurström, Carmen F +11 more
core +3 more sources
mRNA Vaccine Delivery Techniques
, 2023 mRNA vaccines offer streamlined manufacturing, rapid development during health crises, and a safe profile with strong immune responses. The main advantage of mRNA vaccines is that it can be developed more quickly than traditional vaccines and unlike traditional vaccines which uses weakened or inactivated viruses, mRNA vaccines do not introduce the ...
openaire +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Lipid-based mRNA vaccine delivery systems
Expert Review of Vaccines, 2014 Synthetic mRNAs can become biopharmaceutics allowing vaccination against cancer, bacterial and virus infections. Clinical trials with direct administration of synthetic mRNAs encoding tumor antigens demonstrated safety and induction of tumor-specific immune responses.
Midoux, Patrick, Pichon, Chantal
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Increased PIP3 activity blocks nanoparticle mRNA delivery [PDF]
Science Advances, 2020 PIP3, a bioactive lipid upstream of the PI3K/AKT/mTOR pathway, decreased protein translated from nanoparticle-delivered mRNA.
Kalina Paunovska +9 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source