Results 31 to 40 of about 132,779 (257)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Differential display analysis of mRNAs in chronic myelogenous leukaemia

Eastern Mediterranean Health Journal, 2001
Analysis of expressed mRNAs with differential display-polymerase chain reaction [DD-PCR] is a powerful tool for the characterization of genes involved in malignant pathways and might identify markers for different phases of chronic myelogenous leukaemia [CML].
M K, el-Awady, N M, Abdalla, A M, Salem, S, Samir, A M, Nour   +4 more
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Cellular transcripts of chicken brain tissues in response to H5N1 and Newcastle disease virus infection

Virology Journal, 2012
Background Highly-pathogenic avian influenza (HPAI) H5N1 and Newcastle disease (ND) viruses are the two most important poultry viruses in the world, with the ability to cause classic central nervous system dysfunction in poultry and migratory birds.
Balasubramaniam Vinod RMT, Wai Tham H, Omar Abdul R, Othman Iekhsan, Hassan Sharifah S   +4 more
doaj   +1 more source

Transcriptome fingerprinting analysis: an approach to explore gene expression patterns in marine microbial communities. [PDF]

PLoS ONE, 2011
Microbial transcriptomics are providing new insights into the functional processes of microbial communities. However, analysis of each sample is still expensive and time consuming.
Montserrat Coll-Lladó, Silvia G Acinas, Cristina Pujades, Carlos Pedrós-Alió   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A segment and epithelium specific messenger ribonucleic acid fragment up-regulated by estradiol in the rat oviduct

Biological Research, 2001
Estradiol accelerates oviductal embryo transport in the rat through changes of genomic expression in oviductal cells. However, the genes involved are unknown.
MARIANA RIOS, SUANY OJEDA, LUIS A VELASQUEZ, KEVIN MAISEY, HORACIO B CROXATTO   +4 more
doaj  

Differential Expression of Sirtuin Family Members in the Developing, Adult, and Aged Rat Brain

Frontiers in Aging Neuroscience, 2014
The sirtuins are NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that play roles in metabolic homeostasis, stress response and potentially aging. This enzyme family resides in different subcellular compartments, and acts on a number of
Elena eSidorova-Darmos, Elena eSidorova-Darmos, Robert G. Wither, Natalya eShulyakova, Natalya eShulyakova, Carl eFisher, Melanie eRatnam, Michelle eAarts, Lothar eLilge, Philippe P. Monnier, Philippe P. Monnier, James Howard Eubanks, James Howard Eubanks, James Howard Eubanks   +13 more
doaj   +1 more source

Repetitive mild traumatic brain injury-induced neurodegeneration and inflammation is attenuated by acetyl-L-carnitine in a preclinical model

Frontiers in Pharmacology, 2023
Repetitive mild traumatic brain injuries (rmTBI) may contribute to the development of neurodegenerative diseases through secondary injury pathways. Acetyl-L-carnitine (ALC) shows neuroprotection through anti-inflammatory effects and via regulation of ...
Matthew I. Hiskens, Matthew I. Hiskens, Katy M. Li, Anthony G. Schneiders, Andrew S. Fenning   +4 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source