Results 221 to 230 of about 4,884,325 (258)

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Nuclear speckles are regulatory hubs for viral and host mRNA expression during HSV-1 infection. [PDF]

Proc Natl Acad Sci U S A
Nadav-Eliyahu S, Bohrer C, Boocholez A, Kinor N, Aho V, Benichou JIC, Mattola S, Salminen S, Niskanen H, Kaikkonen MU, Vihinen-Ranta M, Shav-Tal Y.   +11 more
europepmc   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Dopamine D2 Receptor and Dopamine Transporter mRNA Expression in Addicted Peripheral Blood Lymphocytes. [PDF]

Addict Health
Hamedanian N, Karimipoor M, Amidfar M, Yoosefee S.   +3 more
europepmc   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

mRNA expression of NLRP3 and IL1B in inflammatory bowel diseases: a systematic review and meta-analysis. [PDF]

BMC Gastroenterol
Metselaar PI, Schilder RCH, Kraneveld AD, Te Velde AA, Li Yim AYF.   +4 more
europepmc   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Developmental and geographic transcriptomic variation in Anisakis simplex (s. s.) reveals lncRNA-mediated regulation of mRNA expression. [PDF]

Sci Rep
Stryiński R, Maździarz M, Carrera M, Łopieńska-Biernat E.   +3 more
europepmc   +1 more source

Spatial Control of Light‐Responsive Proteins and Optogenetics Within Hydrogels via Volumetric Bioprinting

Advanced Materials, EarlyView.
Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi, Pere Català, Gabriel Größbacher, Paulina Nuñez Bernal, Olaf Nijssen, Sammy Florczak, Wilco Nijenhuis, Nuria Crusellas‐Villorbina, Bram Nijhoff, Paul Delrot, Jos Malda, Andreas Hierholzer, Martin Fussenegger, Lukas C. Kapitein, Riccardo Levato   +14 more
wiley   +1 more source