Results 61 to 70 of about 18,476,439 (363)
Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
core +1 more source
mRNA processing inEscherichia coli: an activity encoded by the host processes bacteriophage f1 mRNAs
Nucleic Acids Research, 1984 To examine the regions of the male-specific filamentous bacteriophage f1 genome that include signals for mRNA processing, the 5' endpoints of the major in vivo phage mRNAs have been located in the f1 DNA sequence by S1 nuclease mapping. The 5' ends of the purified mRNAs and additional phage-specific RNAs transiently visible early after infection occur ...
Deborah A. Steege, Kendall J. Blumer
openaire +4 more sources
Stem–loop RNA labeling can affect nuclear and cytoplasmic mRNA processing
RNA: A publication of the RNA Society, 2017 The binding of sequence-specific RNA-interacting proteins, such as the bacteriophage MS2 or PP7 coat proteins, to their corresponding target sequences has been extremely useful and widely used to visualize single mRNAs in vivo.
Stephanie Heinrich +3 more
semanticscholar +1 more source
Notch mRNA expression in Drosophila embryos is negatively regulated at the level of mRNA 3' processing. [PDF]
PLoS ONE, 2009 Notch receptor regulates differentiation of almost all tissues and organs during animal development. Many mechanisms function at the protein level to finely regulate Notch activity.
Andrew K Shepherd +2 more
doaj +1 more source
Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation. [PDF]
PLoS ONE, 2009 BACKGROUND:Metazoan replication-dependent histone mRNAs terminate in a conserved stem-loop structure rather than a polyA tail. Formation of this unique mRNA 3' end requires Stem-loop Binding Protein (SLBP), which directly binds histone pre-mRNA and ...
Harmony R Salzler +3 more
doaj +1 more source
Acta Biochimica et Biophysica SinicaIn eukaryotic cells, gene expression begins with transcription in the nucleus, followed by the maturation of messenger RNAs (mRNAs). These mRNA molecules are then exported to the cytoplasm through the nuclear pore ...
Chen Suli +3 more
doaj +1 more source
3'-end processing of pre-mRNA in eukaryotes [PDF]
FEMS microbiology reviews, 1999 3'-Ends of almost all eukaryotic mRNAs are generated by endonucleolytic cleavage and addition of a poly(A) tail. In mammalian cells, the reaction depends on the sequence AAUAAA upstream of the cleavage site, a degenerate GU-rich sequence element downstream of the cleavage site and stimulatory sequences upstream of AAUAAA.
Wahle, Elmar, Rüeggsegger, Ursula
openaire +4 more sources
BMC Genomics, 2016 Trypanosoma brucei is a unicellular parasite which multiplies in mammals (bloodstream form) and Tsetse flies (procyclic form). Trypanosome RNA polymerase II transcription is polycistronic, individual mRNAs being excised by trans splicing and ...
E. B. Antwi +12 more
semanticscholar +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
A microfluidic processor for gene expression profiling of single human embryonic stem cells [PDF]
, 2008 The gene expression of human embryonic stem cells (hESC) is a critical aspect for understanding the normal and pathological development of human cells and tissues.
Chen, Yan +6 more
core +1 more source