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mRNA therapeutics in cancer immunotherapy [PDF]
Molecular Cancer, 2021 Synthetic mRNA provides a template for the synthesis of any given protein, protein fragment or peptide and lends itself to a broad range of pharmaceutical applications, including different modalities of cancer immunotherapy. With the ease of rapid, large
Jan D. Beck +6 more
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mRNA therapeutics: New vaccination and beyond [PDF]
Fundamental Research, 2023 The idea of mRNA therapy had been conceived for decades before it came into reality during the Covid-19 pandemic. The mRNA vaccine emerges as a powerful and general tool against new viral infections, largely due to its versatility and rapid development ...
Huan-Huan Wei +2 more
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Nanoformulations targeting immune cells for cancer therapy: mRNA therapeutics [PDF]
Bioactive Materials, 2023 The approved worldwide use of two messenger RNA (mRNA) vaccines (BNT162b2 and mRNA-1273) in late 2020 has proven the remarkable success of mRNA therapeutics together with lipid nanoformulation technology in protecting people against coronaviruses during ...
Wei Yang +6 more
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The Pivotal Role of Chemical Modifications in mRNA Therapeutics [PDF]
Frontiers in Cell and Developmental Biology, 2022 After over a decade of development, mRNA has recently matured into a potent modality for therapeutics. The advantages of mRNA therapeutics, including their rapid development and scalability, have been highlighted due to the SARS-CoV-2 pandemic, in which ...
Albert Liu +3 more
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Unraveling the potential: mRNA therapeutics in oncology [PDF]
Frontiers in OncologyMessenger ribonucleic acid (mRNA) technology is a promising platform for cancer immunotherapy. Unlike traditional vaccines that prevent infectious diseases, mRNA’s role in oncology is to stimulate or enhance the immune response against tumor antigens ...
Karol Gawalski +7 more
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mRNA therapeutics: Transforming medicine through innovation in design, delivery, and disease treatment [PDF]
Molecular Therapy: Nucleic AcidsmRNA therapeutics have revolutionized medicine, offering a versatile platform to address previously untreatable diseases. Recent advancements in biotechnology have enabled the efficient production of functional proteins, antibodies, and peptides via mRNA,
Mark Akinola Ige +7 more
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Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines [PDF]
ExplorationMessenger RNA (mRNA) therapeutics and vaccines have recently gained particular prominence following the COVID‐19 epidemic. However, clinical translation of mRNAs is critically dependent on efficient and safe delivery in vivo.
Qi Li +6 more
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Cell-Specific mRNA Therapeutics for Cardiovascular Diseases and Regeneration [PDF]
Journal of Cardiovascular Development and DiseaseCardiovascular diseases (CVDs) represent a significant global health burden, demanding innovative therapeutic approaches. In recent years, mRNA therapeutics have emerged as a promising strategy to combat CVDs effectively.
Raj Kishore, Ajit Magadum
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Psychotropic drugs interaction with the lipid nanoparticle of COVID-19 mRNA therapeutics [PDF]
Frontiers in Pharmacology, 2022 The messenger RNA (mRNA) vaccines for COVID-19, Pfizer-BioNTech and Moderna, were authorized in the US on an emergency basis in December of 2020. The rapid distribution of these therapeutics around the country and the world led to millions of people ...
Adonis Sfera +9 more
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Enabling mRNA Therapeutics: Current Landscape and Challenges in Manufacturing [PDF]
Biomolecules, 2023 Recent advances and discoveries in the structure and role of mRNA as well as novel lipid-based delivery modalities have enabled the advancement of mRNA therapeutics into the clinical trial space.
Maryam Youssef +3 more
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