Results 181 to 190 of about 287,741 (287)

Poly(carboxybetaine) lipids enhance mRNA therapeutics efficacy and reduce their immunogenicity. [PDF]

Nat Mater
Luozhong S, Liu P, Li R, Yuan Z, Debley E, Chen Y, Hu Y, Cao Z, Cui M, McIlhenny K, McCurdy C, Bhashyam D, Wilkens S, Zhang P, Kwan A, Grossman M, Lai R, Ma Y, Lipkin S, Jiang S.   +19 more
europepmc   +1 more source

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across. [PDF]

Adv Drug Deliv Rev, 2021
Minnaert AK, Vanluchene H, Verbeke R, Lentacker I, De Smedt SC, Raemdonck K, Sanders NN, Remaut K.   +7 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

On-patient medical record and mRNA therapeutics using intradermal microneedles. [PDF]

Nat Mater
Han J, Kanelli M, Liu Y, Daristotle JL, Pardeshi A, Forster TA, Karchin A, Folk B, Murmann L, Tostanoski LH, Carrasco SE, Alsaiari SK, Wang EY, Tran K, Zhang L, Eshaghi B, Levy L, Pyon S, Sloane C, Lin SQ, Lau A, Perkinson CF, Bawendi MG, Barouch DH, Durand F, Langer R, Jaklenec A.   +26 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

3AIM-seq: Quality assessment of mRNA therapeutics using sequencing for 3' poly(A) tails of in vitro-transcribed mRNA. [PDF]

Mol Ther
Seo J, Park HJ, Oh A, Jeong CB, Kim S, Lee S, Kim C, Chang H, Nam JH, Park D.   +9 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Editorial on Special Issue "State-of-Art in mRNA Therapeutics and Gene Delivery". [PDF]

Pharmaceutics
Mendonça LS.
europepmc   +1 more source

Oral selinexor–dexamethasone for triple-class refractory multiple myeloma [PDF]

, 2019
al., et, Vij, Ravi
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source