Results 11 to 20 of about 287,741 (287)
mRNA as a Therapeutics: Understanding mRNA Vaccines [PDF]
Advanced Pharmaceutical Bulletin, 2022 Vaccination is one of the important approaches in the prevention and control of diseases. Although the capacity to present antigens other than the disease-specific antigen in the traditional vaccine composition provides a potential benefit by increasing ...
Ferdi Oğuz, Harika Atmaca
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mRNA-Based Therapeutics in Cancer Treatment
Pharmaceutics, 2023 Over the past two decades, significant technological innovations have led to messenger RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic vaccines, protein replacement therapies, and genome engineering.
Han Sun +4 more
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Application of mRNA Technology in Cancer Therapeutics
Vaccines, 2022 mRNA-based therapeutics pose as promising treatment strategies for cancer immunotherapy. Improvements in materials and technology of delivery systems have helped to overcome major obstacles in generating a sufficient immune response required to fight a ...
Yesim Eralp
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The Delivery of mRNA Vaccines for Therapeutics
Life, 2022 mRNA vaccines have been revolutionary in combating the COVID-19 pandemic in the past two years. They have also become a versatile tool for the prevention of infectious diseases and treatment of cancers.
Nitika, Jiao Wei, Ai-Min Hui
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Composition of lipid nanoparticles for targeted delivery: application to mRNA therapeutics [PDF]
Frontiers in PharmacologyToday, lipid nanoparticles (LNPs) are some of the main delivery systems for mRNA-based therapeutics. The scope of LNP applications in terms of RNA is not limited to antiviral vaccines but encompasses anticancer drugs and therapeutics for genetic ...
Olga Vasileva +5 more
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Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria [PDF]
Nature CommunicationsMessenger RNA (mRNA) therapeutics delivered via lipid nanoparticles hold the potential to treat metabolic diseases caused by protein deficiency, including propionic acidemia (PA), methylmalonic acidemia (MMA), and phenylketonuria (PKU).
Rena Baek +17 more
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Current Analytical Strategies for mRNA-Based Therapeutics
MoleculesRecent advancements in mRNA technology, utilized in vaccines, immunotherapies, protein replacement therapies, and genome editing, have emerged as promising and increasingly viable treatments.
Julien Camperi +5 more
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Modified mRNA Therapeutics for Heart Diseases. [PDF]
Int J Mol Sci, 2022 Cardiovascular diseases (CVD) remain a substantial global health problem and the leading cause of death worldwide. Although many conventional small-molecule treatments are available to support the cardiac function of the patient with CVD, they are not effective as a cure.
Magadum A.
europepmc +4 more sources
RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure [PDF]
, 2009 Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs.
Allison, Simon J., Milner, Jo
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Characterization of mRNA therapeutics
Mass Spectrometry Reviews, 2023 AbstractTherapeutic messenger RNAs (mRNAs) have emerged as powerful tools in the treatment of complex diseases, especially for conditions that lack efficacious treatment. The successful application of this modality can be attributed to its ability to encode entire proteins.
Guilherme J, Guimaraes +2 more
openaire +2 more sources