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mRNA-based cancer therapeutics
Nature Reviews Cancer, 2023Due to the fact that mRNA technology allows the production of diverse vaccines and treatments in a shorter time frame and with reduced expense compared to conventional approaches, there has been a surge in the use of mRNA-based therapeutics in recent years.
Chuang Liu +5 more
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Nanoplatforms for mRNA Therapeutics
Advanced Therapeutics, 2020AbstractmRNA‐based therapeutics are a unique class of drugs for treatment of human diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their surface charge prevents them from direct cell entry, they need to be packaged into specially designed delivery platforms to exert their activities.
Chaoyang Meng +4 more
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Unlocking the promise of mRNA therapeutics
Nature Biotechnology, 2022The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19) has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical trials of mRNA therapeutics include studies of paracrine vascular endothelial growth factor (VEGF) mRNA for heart failure and of CRISPR-Cas9 mRNA for a congenital liver ...
Eduarde Rohner +4 more
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Lipid Nanoparticle–mRNA Formulations for Therapeutic Applications
Accounts of Chemical Research, 2021After decades of extensive fundamental studies and clinical trials, lipid nanoparticles (LNPs) have demonstrated effective mRNA delivery such as the Moderna and Pfizer-BioNTech vaccines fighting against COVID-19. Moreover, researchers and clinicians have been investigating mRNA therapeutics for a variety of therapeutic indications including protein ...
Chang Wang, Yuebao Zhang, Yizhou Dong
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Therapeutic mRNA delivery to leukocytes
Journal of Controlled Release, 2019In the past few years mRNA molecules have become an attractive class of new drugs with numerous opportunities. mRNA therapeutics holds great potential for the treatment of a variety of diseases and is an emerging field both in academia and in the pharma industry.
Granot-Matok, Yasmin +4 more
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Low-power therapeutic lasers on mRNA levels
Lasers in Medical Science, 2022Gene expression evaluation in cells and biological tissues has been crucial for research in biology, medicine, biotechnology, and diagnostic. Messenger ribonucleic acid (mRNA) levels show relationship with gene expression, and they can be measured by real-time quantitative polymerase chain reaction (RT-qPCR) for the quantification of steady-state mRNA ...
Adenilson, de Souza da Fonseca +3 more
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Therapeutic mRNA Engineering from Head to Tail
Accounts of Chemical Research, 2021Synthetic messenger RNA (mRNA), once delivered into cells, can be readily translated into proteins by ribosomes, which do not distinguish exogenous mRNAs from endogenous transcripts. Until recently, the intrinsic instability and immunostimulatory property of exogenous RNAs largely hindered the therapeutic application of synthetic mRNAs. Thanks to major
Longfei Jia, Shu-Bing Qian
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Improved translation efficiency of therapeutic mRNA
Gene, 2019Recent developments in the field of the messenger RNA and its advantages versus DNA have led to a renewed interest in mRNA-based technologies. Despite its advantages, mRNA therapy has a number of drawbacks including low amount of mRNA production, short-term existence of mRNA and mRNA-mediated protein within the cell, severe mRNA cytotoxicity, and ...
Farzaneh Zarghampoor +4 more
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Synthetic mRNA for ex vivo therapeutic applications
Drug Metabolism and Pharmacokinetics, 2022Synthetic mRNA is attracting much attention as a new drug modality. Now, there is great interest in the next applications of mRNA medicines, especially for therapeutic purposes of various diseases. Not only in vivo applicable mRNA medicines, there are many researches using ex vivo or in vitro mRNA transfection, some of which are already used in the ...
Hideyuki, Nakanishi, Keiji, Itaka
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mRNA-based therapeutics–Advances and perspectives
Biochemistry (Moscow), 2016In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in vivo. Considerable attention is given to the use of liposomes and nanoparticles containing lipids and polymers for the mRNA delivery.
O V, Sergeeva +2 more
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